HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	21516116
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 543
+	Mm
		431348 DVL2_MOUSE (13-736): 0: 549: 96.69		SRC_MOUSE (1-543): 0: 599: 73.67
+	Mm
		465774 DVL2_MOUSE (13-736): 0: 549: 96.69		HCK_MOUSE (1-541): 0: 530: 56.93
+	Hs
		159472 DVL2_HUMAN (1-736): 0: 545: 100.00		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69
+	Hs
		159456 DVL2_HUMAN (1-736): 0: 545: 100.00		ABL1_HUMAN (41-543): 1.77e-161: 490: 39.10
+	Dm
		362466 DSH_DROME (9-563): 2.98e-121: 378: 46.64		ABL_DROME (82-543): 6.12e-160: 497: 42.22
+	Rn
		723904 DLG4_RAT (112-707): 5.57e-72: 250: 15.95		SRC_RAT (1-543): 0: 601: 73.67
+	Mm
		431355 DLG4_MOUSE (112-707): 3.19e-72: 251: 16.27		SRC_MOUSE (1-543): 0: 599: 73.67
+	Hs
		440486 DLG4_HUMAN (112-707): 3.91e-72: 250: 15.95		FYN_HUMAN (1-543): 0: 584: 72.16
+	Mm
		440284 DLG1_MOUSE (94-707): 2.4e-83: 285: 15.77		LCK_MOUSE (83-541): 0: 544: 60.78
+	Hs
		440052 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		LCK_HUMAN (83-541): 0: 542: 60.78
+	Hs
		463035 AFAD_HUMAN (256-712): 5.05e-48: 186: 21.41		YES_HUMAN (1-543): 0: 618: 100.00
+	Ce
		112331 Q18239_CAEEL (14-643): 3.04e-92: 305: 28.83		SRC1_CAEEL (1-541): 2.92e-170: 494: 47.02
+	Hs
		463488 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69
+	Hs
		557191 AFAD_HUMAN (256-712): 5.05e-48: 186: 21.41		SRC_HUMAN (1-543): 0: 602: 74.22
+	Ce
		397858 MIG5_CAEEL (12-558): 1.99e-78: 267: 26.01		ABL1_CAEEL (4-543): 8.85e-166: 504: 36.99
+	Hs
		440614 RIMS1_HUMAN (92-722): 1.81e-46: 181: 14.15		FYN_HUMAN (1-543): 0: 584: 72.16
+	Hs
		932062 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		EPHA4_HUMAN (4-542): 1.19e-155: 471: 25.00
+	Hs
		463423 AFAD_HUMAN (256-712): 5.05e-48: 186: 21.41		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69
+	Hs
		463837 NEB1_HUMAN (93-347): 4.81e-43: 170: 17.58		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69
+	Hs
		362314 RIMS1_HUMAN (92-722): 1.81e-46: 181: 14.15		ABL1_HUMAN (41-543): 1.77e-161: 490: 39.10