HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: STAM2 (O75886)
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)
Gene: STAM2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.961

The method score is based on:

Property Details
Experiments 12551915, 35271311, 20504764, 16429130, 16189514, 15113837, 13679051
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains FYVE~VHS, VHS~VHS
Common GO terms GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0016236 - macroautophagy
GO:0031901 - early endosome membrane
GO:0033565 - ESCRT-0 complex
and 5 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 777
Hs

1 525
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ce
+ Ce
+ Dm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024