HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.672

Property	Details
Experiments	31340145, 36398662, 31867777, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 975
+	Hs
		159556 DVL2_HUMAN (1-736): 0: 545: 100.00		NEDD4_HUMAN (100-975): 0: 801: 61.35
+	Hs
		159802 DVL2_HUMAN (1-736): 0: 545: 100.00		ITCH_HUMAN (9-972): 0: 795: 32.96
+	Hs
		159845 DVL2_HUMAN (1-736): 0: 545: 100.00		WWP1_HUMAN (1-972): 0: 787: 32.96
+	Hs
		159326 DVL1_HUMAN (11-736): 8.13e-163: 488: 56.04		NEDD4_HUMAN (100-975): 0: 801: 61.35
+	Hs
		159392 DVL1_HUMAN (11-736): 8.13e-163: 488: 56.04		ITCH_HUMAN (9-972): 0: 795: 32.96
+	Hs
		131572 DVL2_HUMAN (1-736): 0: 545: 100.00		WWP2_HUMAN (213-972): 0: 732: 36.95
+	Hs
		1371403 DVL3_HUMAN (11-736): 5.52e-160: 481: 64.77		ITCH_HUMAN (9-972): 0: 795: 32.96
+	Hs
		159397 DVL1_HUMAN (11-736): 8.13e-163: 488: 56.04		WWP1_HUMAN (1-972): 0: 787: 32.96
+	Hs
		1371432 DVL3_HUMAN (11-736): 5.52e-160: 481: 64.77		WWP1_HUMAN (1-972): 0: 787: 32.96
+	Hs
		131571 DVL1_HUMAN (11-736): 8.13e-163: 488: 56.04		WWP2_HUMAN (213-972): 0: 732: 36.95
+	Hs
		159370 DVL1_HUMAN (11-736): 8.13e-163: 488: 56.04		HUWE1_HUMAN (522-973): 2.79e-163: 534: 41.27
+	Hs
		1280385 DVL3_HUMAN (11-736): 5.52e-160: 481: 64.77		HUWE1_HUMAN (522-973): 2.79e-163: 534: 41.27
+	Hs
		1091527 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		HUWE1_HUMAN (522-973): 2.79e-163: 534: 41.27
+	Mm
		59029 DVL2_MOUSE (13-736): 0: 549: 96.69		SMUF2_MOUSE (21-418): 1.38e-33: 141: 21.45
+	Hs
		159863 DVL2_HUMAN (1-736): 0: 545: 100.00		SMUF2_HUMAN (21-418): 1.09e-33: 141: 21.20
+	Hs
		159869 DVL2_HUMAN (1-736): 0: 545: 100.00		SMUF1_HUMAN (17-422): 6.74e-32: 135: 19.57
+	Mm
		1221615 DVL2_MOUSE (13-736): 0: 549: 96.69		SMUF1_MOUSE (17-388): 1.12e-27: 122: 16.36
+	Mm
		59023 DVL1_MOUSE (11-736): 2.67e-170: 507: 57.32		SMUF2_MOUSE (21-418): 1.38e-33: 141: 21.45
+	Hs
		159896 DVL2_HUMAN (1-736): 0: 545: 100.00		HECW2_HUMAN (113-602): 3.9e-20: 98.8: 15.81
+	Hs
		159368 DVL1_HUMAN (11-736): 8.13e-163: 488: 56.04		HECW1_HUMAN (112-640): 1.65e-18: 93.8: 13.33