HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: HECW2 (Q9P2P5)
E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)
Gene: HECW2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 1572
+	Hs
		159368 DVL1_HUMAN (11-736): 8.13e-163: 488: 56.04		HECW1_HUMAN (1-1572): 0: 1165: 55.24
+	Hs
		159370 DVL1_HUMAN (11-736): 8.13e-163: 488: 56.04		HUWE1_HUMAN (1007-1571): 6.06e-165: 557: 30.48
+	Hs
		1280385 DVL3_HUMAN (11-736): 5.52e-160: 481: 64.77		HUWE1_HUMAN (1007-1571): 6.06e-165: 557: 30.48
+	Hs
		1091527 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		HUWE1_HUMAN (1007-1571): 6.06e-165: 557: 30.48
+	Mm
		59029 DVL2_MOUSE (13-736): 0: 549: 96.69		SMUF2_MOUSE (177-504): 7.87e-45: 177: 13.83
+	Hs
		159863 DVL2_HUMAN (1-736): 0: 545: 100.00		SMUF2_HUMAN (177-504): 3.44e-45: 178: 13.83
+	Mm
		59023 DVL1_MOUSE (11-736): 2.67e-170: 507: 57.32		SMUF2_MOUSE (177-504): 7.87e-45: 177: 13.83
+	Hs
		159556 DVL2_HUMAN (1-736): 0: 545: 100.00		NEDD4_HUMAN (265-596): 3e-21: 103: 10.88
+	Hs
		159809 DVL2_HUMAN (1-736): 0: 545: 100.00		NED4L_HUMAN (616-1033): 3.07e-17: 90.1: 14.48
+	Mm
		1221615 DVL2_MOUSE (13-736): 0: 549: 96.69		SMUF1_MOUSE (680-902): 1.83e-13: 77.8: 18.03
+	Hs
		131572 DVL2_HUMAN (1-736): 0: 545: 100.00		WWP2_HUMAN (665-1078): 1.98e-14: 80.8: 16.39
+	Hs
		159845 DVL2_HUMAN (1-736): 0: 545: 100.00		WWP1_HUMAN (616-1034): 1.14e-13: 78.5: 15.33
+	Hs
		159802 DVL2_HUMAN (1-736): 0: 545: 100.00		ITCH_HUMAN (166-495): 1.4e-12: 75.1: 12.93
+	Hs
		159869 DVL2_HUMAN (1-736): 0: 545: 100.00		SMUF1_HUMAN (680-902): 1.41e-12: 74.7: 15.19
+	Hs
		159326 DVL1_HUMAN (11-736): 8.13e-163: 488: 56.04		NEDD4_HUMAN (265-596): 3e-21: 103: 10.88
+	Hs
		131571 DVL1_HUMAN (11-736): 8.13e-163: 488: 56.04		WWP2_HUMAN (665-1078): 1.98e-14: 80.8: 16.39
+	Hs
		159397 DVL1_HUMAN (11-736): 8.13e-163: 488: 56.04		WWP1_HUMAN (616-1034): 1.14e-13: 78.5: 15.33
+	Hs
		159392 DVL1_HUMAN (11-736): 8.13e-163: 488: 56.04		ITCH_HUMAN (166-495): 1.4e-12: 75.1: 12.93
+	Hs
		1371432 DVL3_HUMAN (11-736): 5.52e-160: 481: 64.77		WWP1_HUMAN (616-1034): 1.14e-13: 78.5: 15.33
+	Hs
		1371403 DVL3_HUMAN (11-736): 5.52e-160: 481: 64.77		ITCH_HUMAN (166-495): 1.4e-12: 75.1: 12.93