HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: CSF1R (P07333)
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Gene: CSF1R

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 972
+	Hs
		159856 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		PGFRB_HUMAN (22-967): 5.22e-180: 553: 31.31
+	Hs
		159875 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		PGFRA_HUMAN (1-910): 7.32e-178: 547: 31.95
+	Hs
		276989 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		PGFRB_HUMAN (22-967): 5.22e-180: 553: 31.31
+	Hs
		276999 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		PGFRA_HUMAN (1-910): 7.32e-178: 547: 31.95
+	Hs
		557217 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		PGFRA_HUMAN (1-910): 7.32e-178: 547: 31.95
+	Hs
		159889 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR3_HUMAN (13-300): 6.13e-55: 207: 15.92
+	Hs
		159885 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR2_HUMAN (32-209): 3.68e-27: 121: 15.53
+	Hs
		159864 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR1_HUMAN (32-209): 4.95e-24: 110: 14.56
+	Hs
		159888 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		FGFR4_HUMAN (32-215): 6.05e-23: 107: 15.71
+	Hs
		277004 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		FGFR3_HUMAN (13-300): 6.13e-55: 207: 15.92
+	Hs
		609455 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		FGFR3_HUMAN (13-300): 6.13e-55: 207: 15.92
+	Hs
		277002 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		FGFR2_HUMAN (32-209): 3.68e-27: 121: 15.53
+	Hs
		276996 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		FGFR1_HUMAN (32-209): 4.95e-24: 110: 14.56
+	Hs
		277003 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		FGFR4_HUMAN (32-215): 6.05e-23: 107: 15.71
+	Hs
		601604 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		FGFR2_HUMAN (32-209): 3.68e-27: 121: 15.53
+	Hs
		601561 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		FGFR2_HUMAN (32-209): 3.68e-27: 121: 15.53
+	Hs
		508231 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		FGFR1_HUMAN (32-209): 4.95e-24: 110: 14.56
+	Hs
		608158 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		FGFR4_HUMAN (32-215): 6.05e-23: 107: 15.71
+	Hs
		508131 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		FGFR1_HUMAN (32-209): 4.95e-24: 110: 14.56
+	Hs
		608072 STAM1_HUMAN (4-172): 1.45e-42: 164: 28.40		FGFR4_HUMAN (32-215): 6.05e-23: 107: 15.71