Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: TS101 (Q99816)
Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)
Gene: TSG101

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 0.60 0.762

The method score is based on:

Property Details
Experiments 16189514, 27764233, 12802020, 35271311, 21070952, 19542561, 12900394, 12900395, 17182674, 28581508, 17229889, 17320394, 31515488
Identification Methods two hybrid, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, isothermal titration calorimetry, two hybrid array, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005768 - endosome
GO:0005769 - early endosome
GO:0005829 - cytosol
GO:0008285 - negative regulation of cell population proliferation
GO:0016236 - macroautophagy
and 8 others

more...

Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 777
Hs

1 390
+ Mm
+ Hs
+ Hs
+ Hs
+ Ce
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ Sc
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024