HitPredict

Interactor 1: GOSR2 (O14653)
Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin)
Gene: GOSR2

Interactor 2: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	30833792, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Synaptobrevin~V-SNARE_C
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 212 Hs			1 116
+	Hs
		328714 VTI1A_HUMAN (2-210): 3.4e-52: 169: 11.96		VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00
+	Dm
		1263469 GOSR2_DROME (1-211): 5.04e-53: 171: 41.12		Q7JYX5_DROME (4-96): 8e-33: 115: 31.18
+	Hs
		160228 GOSR2_HUMAN (1-212): 5.81e-61: 191: 100.00		VAMP4_HUMAN (3-73): 1.95e-25: 94.6: 29.58
+	Dm
		614955 GOSR2_DROME (1-211): 5.04e-53: 171: 41.12		SYB_DROME (2-88): 1.37e-29: 105: 39.08
+	At
		235609 VTI11_ARATH (1-191): 2.82e-50: 164: 14.36		VA711_ARATH (4-95): 6.17e-28: 103: 22.58
+	Hs
		328757 VTI1B_HUMAN (2-190): 7.64e-44: 148: 14.36		VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00
+	Rn
		1224615 VTI1A_RAT (2-211): 8.39e-52: 168: 12.09		VAMP1_RAT (2-78): 9.18e-27: 97.3: 37.66
+	Dm
		1263478 Q9W0N6_DROME (1-212): 7.23e-45: 150: 17.89		Q7JYX5_DROME (4-96): 8e-33: 115: 31.18
+	Hs
		278542 VTI1A_HUMAN (2-210): 3.4e-52: 169: 11.96		VAMP4_HUMAN (3-73): 1.95e-25: 94.6: 29.58
+	Hs
		1383304 VTI1A_HUMAN (2-210): 3.4e-52: 169: 11.96		VAMP8_HUMAN (2-73): 2.39e-25: 93: 26.39
+	Hs
		1154704 VTI1A_HUMAN (2-210): 3.4e-52: 169: 11.96		VAMP3_HUMAN (2-72): 1.48e-24: 91.1: 38.03
+	Mm
		312202 VTI1B_MOUSE (2-210): 1.27e-49: 162: 14.88		VAMP7_MOUSE (4-94): 2.35e-25: 96.5: 31.87
+	Dm
		614973 Q9W0N6_DROME (1-212): 7.23e-45: 150: 17.89		SYB_DROME (2-88): 1.37e-29: 105: 39.08
+	Hs
		908061 VTI1B_HUMAN (2-190): 7.64e-44: 148: 14.36		VAMP7_HUMAN (4-96): 3.28e-25: 96.1: 31.18
+	Hs
		278577 VTI1B_HUMAN (2-190): 7.64e-44: 148: 14.36		VAMP4_HUMAN (3-73): 1.95e-25: 94.6: 29.58
+	Hs
		1414887 VTI1B_HUMAN (2-190): 7.64e-44: 148: 14.36		VAMP8_HUMAN (2-73): 2.39e-25: 93: 26.39
+	Hs
		1154778 VTI1B_HUMAN (2-190): 7.64e-44: 148: 14.36		VAMP3_HUMAN (2-72): 1.48e-24: 91.1: 38.03
+	Sc
		751602 VTI1_YEAST (3-194): 2e-36: 128: 10.55		SNC2_YEAST (2-73): 1.07e-23: 89.6: 23.61
+	Sc
		1046463 VTI1_YEAST (3-194): 2e-36: 128: 10.55		NYV1_YEAST (9-88): 1.29e-21: 87.6: 20.00
+	Dm
		84843 B7Z0M0_DROME (106-208): 1.03e-15: 72: 17.48		SYB_DROME (2-88): 1.37e-29: 105: 39.08