HitPredict

Interactor 1: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Interactor 2: VTI1B (Q9UEU0)
Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1)
Gene: VTI1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	30833792, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Synaptobrevin~V-SNARE_C
Common GO terms	GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 116 Hs			1 232
+	Hs
		328714 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		VTI1A_HUMAN (7-231): 7.86e-55: 176: 27.56
+	Mm
		312202 VAMP7_MOUSE (4-94): 2.35e-25: 96.5: 31.87		VTI1B_MOUSE (1-232): 4.51e-61: 193: 92.24
+	At
		1374156 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		NPS11_ARATH (1-214): 9.26e-51: 167: 16.67
+	Rn
		1224615 VAMP1_RAT (2-78): 9.18e-27: 97.3: 37.66		VTI1A_RAT (7-232): 5.3e-56: 179: 27.88
+	Dm
		1263478 Q7JYX5_DROME (4-96): 8e-33: 115: 31.18		Q9W0N6_DROME (9-228): 1.2e-48: 161: 22.27
+	At
		866330 VA722_ARATH (5-92): 7.02e-30: 108: 25.00		NPS11_ARATH (1-214): 9.26e-51: 167: 16.67
+	Dm
		1263469 Q7JYX5_DROME (4-96): 8e-33: 115: 31.18		GOSR2_DROME (11-226): 3.84e-47: 156: 17.13
+	Hs
		278542 VAMP4_HUMAN (3-73): 1.95e-25: 94.6: 29.58		VTI1A_HUMAN (7-231): 7.86e-55: 176: 27.56
+	Hs
		908061 VAMP7_HUMAN (4-96): 3.28e-25: 96.1: 31.18		VTI1B_HUMAN (1-232): 7.08e-54: 174: 100.00
+	Hs
		1383304 VAMP8_HUMAN (2-73): 2.39e-25: 93: 26.39		VTI1A_HUMAN (7-231): 7.86e-55: 176: 27.56
+	Hs
		160230 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		GOSR2_HUMAN (11-226): 4.45e-45: 151: 15.07
+	Hs
		278577 VAMP4_HUMAN (3-73): 1.95e-25: 94.6: 29.58		VTI1B_HUMAN (1-232): 7.08e-54: 174: 100.00
+	Hs
		1414887 VAMP8_HUMAN (2-73): 2.39e-25: 93: 26.39		VTI1B_HUMAN (1-232): 7.08e-54: 174: 100.00
+	At
		235609 VA711_ARATH (4-95): 6.17e-28: 103: 22.58		VTI11_ARATH (7-230): 1.24e-49: 163: 26.22
+	Dm
		614973 SYB_DROME (2-88): 1.37e-29: 105: 39.08		Q9W0N6_DROME (9-228): 1.2e-48: 161: 22.27
+	Dm
		614955 SYB_DROME (2-88): 1.37e-29: 105: 39.08		GOSR2_DROME (11-226): 3.84e-47: 156: 17.13
+	Hs
		160228 VAMP4_HUMAN (3-73): 1.95e-25: 94.6: 29.58		GOSR2_HUMAN (11-226): 4.45e-45: 151: 15.07
+	Dm
		84855 Q7JYX5_DROME (4-96): 8e-33: 115: 31.18		B7Z0M0_DROME (110-228): 3.85e-18: 79: 42.86
+	Dm
		84843 SYB_DROME (2-88): 1.37e-29: 105: 39.08		B7Z0M0_DROME (110-228): 3.85e-18: 79: 42.86
+	Dm
		84890 NSYB_DROME (2-84): 8.87e-27: 99.2: 38.55		B7Z0M0_DROME (110-228): 3.85e-18: 79: 42.86