HitPredict

Interactor 1: MYPT1 (O14974)
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)
Gene: PPP1R12A

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0007165 - signal transduction GO:0071889 - 14-3-3 protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1030 Hs			1 245
+	Hs
		161349 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		161353 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		161312 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		161313 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		161359 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		161346 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		883468 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		646759 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		883471 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		647273 Q9H4D1_HUMAN (1-326): 3.17e-70: 251: 20.06		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		683234 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		683652 Q96T11_HUMAN (1-326): 6.74e-70: 251: 20.06		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		683708 Q9H4D1_HUMAN (1-326): 3.17e-70: 251: 20.06		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		980360 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		904467 NOTC2_HUMAN (8-636): 7.56e-77: 279: 18.38		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		883491 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		883467 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		982413 Q96T11_HUMAN (1-326): 6.74e-70: 251: 20.06		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		905022 Q96T11_HUMAN (1-326): 6.74e-70: 251: 20.06		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		905108 Q9H4D1_HUMAN (1-326): 3.17e-70: 251: 20.06		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33