HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	30604749, 31127101, 30804502, 36598580
Identification Methods	pull down, unspecified method, x-ray crystallography, affinity chromatography technology
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	CENP-T_C~SET
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 5537 Hs			1 103
+	Hs
		980344 EHMT1_HUMAN (4886-5533): 5.22e-112: 394: 15.17		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		980155 EHMT2_HUMAN (4886-5533): 3.82e-112: 392: 17.77		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		979726 EZH2_HUMAN (5194-5519): 6.58e-90: 314: 18.91		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Sc
		382090 SET1_YEAST (5160-5537): 2.85e-82: 299: 27.25		H4_YEAST (18-103): 6.16e-41: 132: 90.70
+	Sc
		382185 SET2_YEAST (5266-5536): 1.28e-76: 274: 21.32		H4_YEAST (18-103): 6.16e-41: 132: 90.70
+	Hs
		979532 KMT2A_HUMAN (218-352): 4.01e-30: 135: 26.24		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		980537 KMT2B_HUMAN (79-219): 7.15e-25: 118: 24.31		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		980278 NSD3_HUMAN (175-342): 4.38e-22: 108: 18.29		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		175869 SET1A_HUMAN (5396-5537): 8.52e-22: 107: 46.15		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		355475 NSD2_HUMAN (175-320): 1.72e-16: 90.2: 18.18		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		980277 SETD2_HUMAN (5389-5536): 1.88e-15: 87: 34.23		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		980157 NSD1_HUMAN (1022-1605): 6.13e-15: 85.2: 12.88		H4_HUMAN (1-103): 1.39e-48: 151: 100.00
+	Hs
		980015 KMT2C_HUMAN (1370-1889): 6.09e-09: 65.5: 16.42		H4_HUMAN (1-103): 1.39e-48: 151: 100.00