HitPredict

Interactor 1: HNRDL (O14979)
Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1)
Gene: HNRNPDL

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	20020773, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003677 - DNA binding GO:0003690 - double-stranded DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0010468 - regulation of gene expression
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 420 Hs			1 414
+	Hs
		453323 ROA1_HUMAN (136-317): 5.38e-82: 258: 36.17		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		852036 ROA3_HUMAN (140-317): 8.69e-82: 257: 37.50		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		609836 ROA2_HUMAN (139-356): 1.02e-75: 241: 34.51		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		161942 ROA1_HUMAN (136-317): 5.38e-82: 258: 36.17		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		453229 ROA1_HUMAN (136-317): 5.38e-82: 258: 36.17		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		161962 ROA2_HUMAN (139-356): 1.02e-75: 241: 34.51		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		609770 ROA2_HUMAN (139-356): 1.02e-75: 241: 34.51		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		162035 HNRDL_HUMAN (1-420): 1.19e-90: 282: 100.00		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		161948 HNRDL_HUMAN (1-420): 1.19e-90: 282: 100.00		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		453331 ROA1_HUMAN (136-317): 5.38e-82: 258: 36.17		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		453107 ROA1_HUMAN (136-317): 5.38e-82: 258: 36.17		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		516424 ROA3_HUMAN (140-317): 8.69e-82: 257: 37.50		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		162045 HNRDL_HUMAN (1-420): 1.19e-90: 282: 100.00		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		516358 ROA2_HUMAN (139-356): 1.02e-75: 241: 34.51		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		453351 ROA1_HUMAN (136-317): 5.38e-82: 258: 36.17		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		852054 ROA3_HUMAN (140-317): 8.69e-82: 257: 37.50		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		609857 ROA2_HUMAN (139-356): 1.02e-75: 241: 34.51		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		516511 HNRPD_HUMAN (111-420): 3.55e-62: 206: 56.45		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Dm
		432486 RB27C_DROME (143-407): 8.49e-78: 248: 29.49		ROA1_DROME (179-271): 1.97e-16: 82.1: 24.24