HitPredict

Interactor 1: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Interactor 2: AMOL2 (Q9Y2J4)
Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP)
Gene: AMOTL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.666

Property	Details
Experiments	16189514, 29892012, 31515488
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 642 Hs			1 779
+	Hs
		163952 NDC80_HUMAN (1-642): 3.95e-79: 265: 100.00		AMOT_HUMAN (1-740): 2.71e-70: 252: 32.32
+	Hs
		1196975 TGO1_HUMAN (195-642): 3.73e-29: 126: 15.45		AMOT_HUMAN (1-740): 2.71e-70: 252: 32.32
+	Hs
		164105 NDC80_HUMAN (1-642): 3.95e-79: 265: 100.00		MYO5C_HUMAN (85-502): 3.93e-13: 75.5: 11.37
+	Hs
		1197032 DLG5_HUMAN (259-629): 1.41e-15: 82.9: 13.12		AMOT_HUMAN (1-740): 2.71e-70: 252: 32.32
+	Hs
		164123 NDC80_HUMAN (1-642): 3.95e-79: 265: 100.00		EP15R_HUMAN (483-673): 1.1e-10: 67.4: 13.09
+	Hs
		773002 UACA_HUMAN (191-641): 1.52e-30: 130: 13.88		MYH9_HUMAN (222-767): 1.78e-23: 109: 10.87
+	Hs
		773110 MYH10_HUMAN (175-642): 1.34e-16: 86.3: 11.04		MYH10_HUMAN (56-777): 3.7e-26: 117: 10.67
+	Hs
		773112 MYH10_HUMAN (175-642): 1.34e-16: 86.3: 11.04		MYH11_HUMAN (207-773): 7.3e-24: 110: 11.36
+	Mm
		98073 DESP_MOUSE (190-642): 1.19e-15: 83.5: 15.27		MYH9_MOUSE (167-766): 1.35e-24: 112: 12.70
+	Hs
		772645 MYH10_HUMAN (175-642): 1.34e-16: 86.3: 11.04		MYH9_HUMAN (222-767): 1.78e-23: 109: 10.87
+	Hs
		556902 MYH7_HUMAN (190-642): 2.72e-15: 82.1: 9.55		MYH9_HUMAN (222-767): 1.78e-23: 109: 10.87
+	Hs
		1217577 MRCKB_HUMAN (310-642): 8.31e-19: 93.3: 12.39		MRCKA_HUMAN (242-732): 6.81e-18: 91.3: 12.33
+	Hs
		1217526 MRCKA_HUMAN (149-554): 5.83e-17: 87.5: 12.33		MRCKA_HUMAN (242-732): 6.81e-18: 91.3: 12.33
+	Rn
		236530 MRCKB_RAT (310-642): 6.47e-18: 90.6: 12.13		MRCKA_RAT (140-608): 2.18e-16: 86.3: 11.49
+	Rn
		236526 MRCKA_RAT (336-642): 2.36e-17: 88.7: 10.17		MRCKA_RAT (140-608): 2.18e-16: 86.3: 11.49
+	Rn
		1274668 MRCKB_RAT (310-642): 6.47e-18: 90.6: 12.13		MRCKB_RAT (148-603): 2.1e-15: 83.2: 10.35
+	Hs
		556892 MYH7_HUMAN (190-642): 2.72e-15: 82.1: 9.55		MYH7_HUMAN (334-778): 2.15e-17: 89.7: 10.16
+	Hs
		556973 MYH7_HUMAN (190-642): 2.72e-15: 82.1: 9.55		MYH4_HUMAN (47-508): 2.08e-11: 70.1: 9.96