HitPredict

Interactor 1: SPTN2 (O15020)
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)
Gene: SPTBN2

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21182203
Identification Methods	cosedimentation through density gradient
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2390 Hs			1 530
+	Hs
		369420 SPTB2_HUMAN (3-2390): 0: 712: 61.09		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		211633 ACTN4_HUMAN (56-621): 3.25e-122: 412: 41.70		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		211456 ACTN4_HUMAN (56-621): 3.25e-122: 412: 41.70		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		809148 UTRN_HUMAN (19-2308): 3.65e-86: 318: 14.19		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		521591 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1045473 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		211472 ACTN4_HUMAN (56-621): 3.25e-122: 412: 41.70		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		369158 UTRN_HUMAN (19-2308): 3.65e-86: 318: 14.19		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		368893 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369568 SPTN1_HUMAN (279-2273): 5.34e-78: 291: 18.75		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1068618 PLEC_HUMAN (379-2232): 1.33e-50: 201: 10.46		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		521532 ACTN1_HUMAN (31-766): 7.87e-88: 310: 32.02		NR1H3_HUMAN (65-499): 1.77e-104: 322: 20.97
+	Hs
		369641 PLEC_HUMAN (379-2232): 1.33e-50: 201: 10.46		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		211471 ACTN4_HUMAN (56-621): 3.25e-122: 412: 41.70		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Mm
		580490 ACTN2_MOUSE (33-677): 2.05e-118: 401: 38.77		ANDR_MOUSE (149-407): 1.53e-38: 152: 33.70
+	Hs
		974119 DYST_HUMAN (1807-2150): 4.68e-11: 71: 13.35		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369446 DYST_HUMAN (1807-2150): 4.68e-11: 71: 13.35		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		513834 DMD_HUMAN (275-2194): 6.97e-24: 113: 8.91		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		320227 SPTN4_HUMAN (1248-2382): 2.34e-15: 85.3: 16.21		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57