HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: DAPP1 (Q9UN19)
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa)
Gene: DAPP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	23322602
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 280
+	Mm
		813527 FYN_MOUSE (3-125): 7.97e-36: 130: 22.48		Q91YX7_MOUSE (18-276): 4.47e-59: 203: 24.16
+	Mm
		813518 SH21C_MOUSE (1-132): 1.88e-42: 138: 65.91		FYN_MOUSE (4-280): 1.6e-56: 191: 19.80
+	Dm
		1466640 SRC42_DROME (3-131): 5.92e-37: 133: 26.52		SRC42_DROME (4-280): 4.06e-57: 192: 18.62
+	Hs
		164846 SH21B_HUMAN (1-132): 1.92e-40: 133: 100.00		SRC_HUMAN (4-280): 1.33e-56: 191: 18.77
+	Mm
		683097 SH21C_MOUSE (1-132): 1.88e-42: 138: 65.91		LYN_MOUSE (3-280): 1.21e-54: 186: 18.37
+	Dm
		1466642 Q9VGK8_DROME (3-129): 1.63e-35: 130: 26.77		SRC42_DROME (4-280): 4.06e-57: 192: 18.62
+	Hs
		440290 FYN_HUMAN (3-125): 8.56e-36: 130: 22.48		FYN_HUMAN (4-280): 3.63e-56: 190: 19.80
+	Hs
		187257 SHIP2_HUMAN (5-102): 1.33e-36: 133: 42.86		LYN_HUMAN (3-280): 7.93e-55: 186: 18.03
+	Mm
		571265 FGR_MOUSE (3-124): 5.58e-36: 130: 24.22		FGR_MOUSE (4-280): 3.14e-55: 187: 18.77
+	Hs
		187238 SHIP2_HUMAN (5-102): 1.33e-36: 133: 42.86		ABL1_HUMAN (8-280): 4.15e-50: 179: 17.61
+	Hs
		439898 FYN_HUMAN (3-125): 8.56e-36: 130: 22.48		LCK_HUMAN (3-280): 8.14e-53: 181: 20.07
+	Mm
		465773 SH21C_MOUSE (1-132): 1.88e-42: 138: 65.91		HCK_MOUSE (3-280): 1.66e-49: 172: 19.73
+	Hs
		362121 FYN_HUMAN (3-125): 8.56e-36: 130: 22.48		ABL1_HUMAN (8-280): 4.15e-50: 179: 17.61
+	Hs
		72376 SHIP2_HUMAN (5-102): 1.33e-36: 133: 42.86		A9UF07_HUMAN (8-280): 1.87e-48: 174: 16.55
+	Hs
		164852 SH21B_HUMAN (1-132): 1.92e-40: 133: 100.00		BLK_HUMAN (4-280): 8.06e-48: 167: 17.47
+	Dm
		362518 Q9VGK8_DROME (3-129): 1.63e-35: 130: 26.77		SRC64_DROME (3-280): 7.41e-46: 163: 15.99
+	Mm
		813529 FYN_MOUSE (3-125): 7.97e-36: 130: 22.48		NCK1_MOUSE (34-127): 8.61e-40: 144: 34.04
+	Hs
		164849 SH21B_HUMAN (1-132): 1.92e-40: 133: 100.00		PLCG1_HUMAN (4-184): 1.97e-22: 98.7: 23.00
+	Hs
		164848 SH21B_HUMAN (1-132): 1.92e-40: 133: 100.00		PLCG2_HUMAN (4-198): 3.64e-21: 95.2: 21.76
+	Mm
		813526 FYN_MOUSE (3-125): 7.97e-36: 130: 22.48		PLCG2_MOUSE (4-198): 3.53e-22: 97.9: 20.83