HitPredict

Interactor 1: MCF2L (O15068)
Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein)
Gene: MCF2L

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.755

Property	Details
Experiments	32203420, 12006984
Identification Methods	fluorescent resonance energy transfer, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1137 Hs			1 193
+	Hs
		166482 MCF2L_HUMAN (1-1137): 0: 816: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		166478 MCF2L_HUMAN (1-1137): 0: 816: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		500932 MCF2_HUMAN (137-1060): 7.99e-171: 529: 45.00		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		500934 MCF2_HUMAN (137-1060): 7.99e-171: 529: 45.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		500931 MCF2_HUMAN (137-1060): 7.99e-171: 529: 45.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		900546 PKHG4_HUMAN (37-961): 2.76e-124: 412: 22.91		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925330 PKHG4_HUMAN (37-961): 2.76e-124: 412: 22.91		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		894327 PKH4B_HUMAN (46-1056): 2.02e-123: 417: 21.76		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		894092 PKHG4_HUMAN (37-961): 2.76e-124: 412: 22.91		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545418 PKHG4_HUMAN (37-961): 2.76e-124: 412: 22.91		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		892408 PKHG4_HUMAN (37-961): 2.76e-124: 412: 22.91		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		925461 ARH40_HUMAN (46-1099): 1.17e-96: 340: 18.10		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		894243 ARH40_HUMAN (46-1099): 1.17e-96: 340: 18.10		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545519 ARH40_HUMAN (46-1099): 1.17e-96: 340: 18.10		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		892502 ARH40_HUMAN (46-1099): 1.17e-96: 340: 18.10		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Dm
		115195 M9PEF7_DROME (70-1101): 1.56e-91: 325: 18.41		RAC1_DROME (1-193): 2.11e-77: 231: 54.12
+	Hs
		855779 VAV2_HUMAN (462-1137): 1.11e-91: 316: 14.75		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		855782 VAV2_HUMAN (462-1137): 1.11e-91: 316: 14.75		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		901037 VAV3_HUMAN (464-1127): 4.4e-91: 313: 15.04		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		855778 VAV2_HUMAN (462-1137): 1.11e-91: 316: 14.75		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33