HitPredict

Interactor 1: SOCS1 (O35716)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1)
Gene: SOCS1

Interactor 2: TF65 (Q04207)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: Rela

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14690596
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0046627 - negative regulation of insulin receptor signaling pathway
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 212 Mm			1 549
+	Hs
		181848 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		TF65_HUMAN (1-549): 0: 631: 87.52
+	Hs
		147412 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		TF65_HUMAN (1-549): 0: 631: 87.52
+	Hs
		147512 SOCS6_HUMAN (68-210): 1.27e-35: 132: 26.22		TF65_HUMAN (1-549): 0: 631: 87.52
+	Hs
		978936 DAPP1_HUMAN (52-202): 1.73e-35: 127: 21.12		TF65_HUMAN (1-549): 0: 631: 87.52
+	Hs
		209033 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		REL_HUMAN (12-491): 8.06e-158: 465: 42.89
+	Hs
		147413 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		REL_HUMAN (12-491): 8.06e-158: 465: 42.89
+	Hs
		147387 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		NFKB1_HUMAN (5-382): 1.19e-142: 437: 32.93
+	Mm
		140058 P85B_MOUSE (60-175): 2.73e-23: 99: 21.77		NFKB1_MOUSE (6-485): 5.81e-151: 459: 28.96
+	Hs
		147418 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		NFAC2_HUMAN (4-527): 6.97e-95: 311: 19.38