HitPredict

Interactor 1: SOCS1 (O35716)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1)
Gene: SOCS1

Interactor 2: CUL5 (Q9D5V5)
Cullin-5 (CUL-5)
Gene: CUL5

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19385048
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 212 Mm			1 780
+	Mm
		1257617 SOCS7_MOUSE (30-210): 6.65e-48: 166: 23.04		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		146692 SOCS7_HUMAN (30-210): 1.96e-47: 165: 22.55		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1265273 SOCS4_MOUSE (8-211): 6.83e-47: 161: 20.28		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		1263831 SOCS4_HUMAN (13-211): 6.4e-45: 156: 19.81		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		181885 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		222648 SOCS5_MOUSE (8-211): 1.94e-41: 148: 20.28		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		256856 SOCS5_HUMAN (8-211): 1.48e-41: 149: 19.81		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		193394 SOCS3_MOUSE (38-208): 4.45e-43: 146: 27.35		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Mm
		1322060 SOCS6_MOUSE (67-210): 8.8e-40: 144: 26.06		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		147440 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		193366 SOCS2_MOUSE (36-212): 5.03e-42: 142: 28.28		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		146642 SOCS2_HUMAN (36-212): 3.26e-42: 142: 28.28		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Mm
		1143676 CISH_MOUSE (10-212): 3.04e-40: 139: 25.59		CUL5_MOUSE (1-780): 0: 783: 100.00
+	Hs
		1274062 CISH_HUMAN (14-212): 1.31e-38: 135: 27.09		CUL5_HUMAN (1-780): 0: 781: 98.46
+	Hs
		1042817 VAV3_HUMAN (12-210): 1.04e-37: 140: 16.08		CUL3_HUMAN (8-780): 0: 743: 22.71
+	Hs
		146625 SOCS2_HUMAN (36-212): 3.26e-42: 142: 28.28		CUL4A_HUMAN (16-780): 0: 733: 24.61
+	Hs
		147421 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		CUL4B_HUMAN (16-780): 0: 726: 25.52
+	Hs
		789064 ABL2_HUMAN (71-193): 1.95e-36: 136: 19.05		CUL4A_HUMAN (16-780): 0: 733: 24.61
+	Hs
		181856 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		CUL2_HUMAN (10-780): 0: 688: 26.37
+	Hs
		1041477 CISH_HUMAN (14-212): 1.31e-38: 135: 27.09		CUL2_HUMAN (10-780): 0: 688: 26.37