HitPredict

Interactor 1: SOCS1 (O35716)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1)
Gene: SOCS1

Interactor 2: IRF1 (P15314)
Interferon regulatory factor 1 (IRF-1)
Gene: IRF1

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	10820262
Identification Methods	electrophoretic mobility supershift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0042532 - negative regulation of tyrosine phosphorylation of STAT protein
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 212 Mm			1 329
+	Hs
		181780 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		IRF1_HUMAN (1-329): 5.33e-176: 491: 84.50
+	Hs
		181784 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		IRF2_HUMAN (1-260): 7.61e-115: 337: 45.06
+	Mm
		193341 SOCS1_MOUSE (1-212): 3.72e-50: 163: 100.00		IRF8_MOUSE (7-199): 2.28e-54: 184: 29.02
+	Hs
		181861 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		IRF3_HUMAN (1-161): 5.39e-50: 173: 27.95
+	Mm
		619089 DAPP1_MOUSE (52-201): 7.61e-38: 134: 20.63		IRF8_MOUSE (7-199): 2.28e-54: 184: 29.02
+	Hs
		181882 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		IRF7_HUMAN (4-111): 8.86e-37: 139: 30.77
+	Hs
		147439 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		IRF7_HUMAN (4-111): 8.86e-37: 139: 30.77