HitPredict

Interactor 1: FYB1 (O15117)
FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)
Gene: FYB1

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	22074159
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~SH3_2, SH3_1~SH3_2, SH3_2~SH3_2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0015629 - actin cytoskeleton GO:0032991 - protein-containing complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 783 Hs			1 304
+	Hs
		167748 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		167733 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17
+	Hs
		167742 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		167751 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		167730 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		167740 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Mm
		193087 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		GRAP2_MOUSE (18-192): 6.73e-14: 72.9: 19.79
+	Hs
		554292 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Ce
		136804 UNC89_CAEEL (14-669): 4.99e-25: 114: 11.94		VAV_CAEEL (13-194): 4.87e-22: 98.4: 23.94
+	Hs
		1186102 MICA3_HUMAN (14-697): 1.07e-26: 119: 10.91		CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12
+	Hs
		924760 PRG4_HUMAN (243-720): 1.33e-15: 83.5: 9.28		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		855816 TITIN_HUMAN (311-745): 7.86e-09: 61.9: 12.22		VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74
+	Hs
		517796 NFH_HUMAN (18-409): 7.32e-12: 71.5: 14.54		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		203218 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		1056926 MDC1_HUMAN (16-730): 7.54e-15: 81.2: 9.50		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		203208 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		203228 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87
+	Hs
		203241 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22