HitPredict

Interactor 1: FYB1 (O15117)
FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)
Gene: FYB1

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	19380743
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~SH3_2, SH3_1~SH3_2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 783 Hs			1 217
+	Hs
		167740 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		167735 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		167737 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Mm
		193088 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		LCK_MOUSE (3-202): 2.89e-37: 137: 28.44
+	Hs
		167733 FYB1_HUMAN (1-783): 3.31e-92: 308: 100.00		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62
+	Hs
		554292 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924760 PRG4_HUMAN (243-720): 1.33e-15: 83.5: 9.28		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		193090 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58
+	Mm
		193089 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		LYN_MOUSE (129-215): 2.66e-11: 64.2: 22.47
+	Mm
		193087 FYB1_MOUSE (1-783): 7.99e-67: 239: 70.52		GRAP2_MOUSE (3-55): 1.57e-10: 61.5: 37.74
+	Hs
		517796 NFH_HUMAN (18-409): 7.32e-12: 71.5: 14.54		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		411582 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		411823 ASPP1_HUMAN (7-477): 1.69e-24: 112: 16.57		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		337335 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		203198 SYNJ1_HUMAN (264-675): 3.42e-09: 62.7: 8.65		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		433560 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522749 MUC1_HUMAN (6-732): 3.39e-28: 124: 9.80		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		433853 MICA3_HUMAN (14-697): 1.07e-26: 119: 10.91		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		433948 ASPP1_HUMAN (7-477): 1.69e-24: 112: 16.57		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		297808 K0754_HUMAN (250-731): 8.54e-16: 84.6: 7.68		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47