HitPredict

Interactor 1: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Interactor 2: OTUB1 (Q96FW1)
Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)
Gene: OTUB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35927303
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Peptidase_C65~UQ_con
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043130 - ubiquitin binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 153 Hs			1 271
+	Hs
		1391085 UB2D4_HUMAN (2-149): 4.15e-76: 224: 38.93		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		906745 UB2D1_HUMAN (2-149): 1.12e-75: 223: 38.93		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		982284 UB2D2_HUMAN (2-149): 3.48e-75: 222: 37.58		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		957165 UB2D3_HUMAN (2-149): 5.81e-74: 219: 36.24		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		1391011 UB2E2_HUMAN (3-148): 1.04e-68: 208: 32.65		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		1381181 UB2E3_HUMAN (3-148): 2.11e-68: 207: 31.97		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		909372 UB2E1_HUMAN (3-148): 6.24e-67: 203: 34.01		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		996003 UB2L3_HUMAN (1-152): 5.62e-66: 199: 55.26		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Hs
		957818 UBE2N_HUMAN (4-151): 5.07e-65: 196: 29.73		OTUB1_HUMAN (1-271): 3.26e-150: 422: 100.00
+	Mm
		957885 UBE2N_MOUSE (4-151): 5.07e-65: 196: 29.73		OTUB1_MOUSE (1-271): 3.19e-150: 422: 99.63
+	Ce
		762745 UBC2_CAEEL (2-149): 3.4e-75: 222: 37.58		OTUBL_CAEEL (3-271): 2.77e-122: 352: 34.42
+	At
		1320255 UBC36_ARATH (4-148): 1.51e-69: 208: 32.41		OTU1_ARATH (31-270): 5.77e-113: 329: 42.37
+	Hs
		957811 UBE2N_HUMAN (4-151): 5.07e-65: 196: 29.73		OTUB2_HUMAN (47-270): 1.26e-104: 305: 47.77