Protein: OTUB2
Ubiquitin thioesterase OTUB2 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB2) (OTU domain-containing ubiquitin aldehyde-binding protein 2) (Otubain-2) (Ubiquitin-specific-processing protease OTUB2)

Gene: OTUB2
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q96DC9

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0006508 - proteolysis
GO:0016579 - protein deubiquitination
GO:0035871 - protein K11-linked deubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508417

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

5

Small-scale

0.920

High

1387355

TRAF6
TNF receptor-associated factor 6

4

9

Small-scale

0.685

High

1387333

TRIM8
E3 ubiquitin-protein ligase TRIM8

3

15

High-throughput

0.654

High

957811

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

11

Small-scale

0.647

High

1154900

NEDD8
Ubiquitin-like protein NEDD8

1

2

Small-scale

0.647

High

1048958

REL
Proto-oncogene c-Rel

3

0

High-throughput

0.646

High

1115584

ASPP2
Apoptosis-stimulating of p53 protein 2

2

1

High-throughput

0.633

High

573200

KPYM
Pyruvate kinase PKM

2

1

Small-scale

0.624

High

1387331

TRI54
Tripartite motif-containing protein 54

3

14

High-throughput

0.611

High

927095

ATX3
Ataxin-3

2

0

High-throughput

0.594

High

1387338

NMRL1
NmrA-like family domain-containing protein 1

2

1

Small-scale

0.584

High

1139105

DAZP2
DAZ-associated protein 2

2

0

High-throughput

0.580

High

1387337

CDIP1
Cell death-inducing p53-target protein 1

2

0

High-throughput

0.580

High

1307766

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

High-throughput

0.573

High

685679

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

Small-scale

0.561

High

1322301

SPART
Spartin

2

1

High-throughput

0.553

High

801454

HSPA9
Stress-70 protein, mitochondrial

2

4

High-throughput

0.549

High

1160240

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.549

High

1339830

PJA1
E3 ubiquitin-protein ligase Praja-1

2

4

Small-scale

0.543

High

848920

MAGAB
Melanoma-associated antigen 11

1

2

High-throughput

0.541

High

517490

GLI2
Zinc finger protein GLI2

1

0

Small-scale

0.537

High

186572

TRI18
E3 ubiquitin-protein ligase Midline-1

1

14

High-throughput

0.523

High

1387327

LZTS2
Leucine zipper putative tumor suppressor 2

1

2

High-throughput

0.523

High

1387347

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

13

High-throughput

0.523

High

1053268

Q05BL1
TP53BP2 protein

1

1

High-throughput

0.515

High

1292611

GPBP1
Vasculin

1

0

High-throughput

0.513

High

1358523

TPC12
Trafficking protein particle complex subunit 12

1

0

High-throughput

0.513

High

140396

SDCB1
Syntenin-1

1

1

Small-scale

0.501

High

1380810

TRI63
E3 ubiquitin-protein ligase TRIM63

1

15

High-throughput

0.501

High

1387326

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

4

High-throughput

0.501

High

1387332

TRI55
Tripartite motif-containing protein 55

1

14

High-throughput

0.501

High

1387348

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

4

High-throughput

0.501

High

465022

SP1
Transcription factor Sp1

1

1

High-throughput

0.500

High

1005937

GTF2I
General transcription factor II-I

1

0

High-throughput

0.493

High

1250752

MPRIP
Myosin phosphatase Rho-interacting protein

1

1

High-throughput

0.489

High

1335238

KCTD6
BTB/POZ domain-containing protein KCTD6

1

1

High-throughput

0.489

High

1387349

NEB1
Neurabin-1

1

1

High-throughput

0.489

High

572120

TRI27
Zinc finger protein RFP

1

4

High-throughput

0.481

High

1089252

TRI26
Tripartite motif-containing protein 26

1

4

High-throughput

0.481

High

1387328

RN126
E3 ubiquitin-protein ligase RNF126

1

4

High-throughput

0.481

High

1387330

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.481

High

1387334

TRIM5
Tripartite motif-containing protein 5

1

4

High-throughput

0.481

High

1387340

TRI39
E3 ubiquitin-protein ligase TRIM39

1

4

High-throughput

0.481

High

350103

SNAI1
Zinc finger protein SNAI1

1

1

Small-scale

0.479

High

372799

MYC
Myc proto-oncogene protein

1

1

Small-scale

0.479

High

409028

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.479

High

447300

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

623478

RO52
E3 ubiquitin-protein ligase TRIM21

1

4

Small-scale

0.479

High

652561

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

2

Small-scale

0.479

High

764958

CTNB1
Catenin beta-1

1

1

Small-scale

0.479

High

807525

IF4A3
Eukaryotic initiation factor 4A-III

1

3

Small-scale

0.479

High

862361

YAP1
Transcriptional coactivator YAP1

1

2

Small-scale

0.479

High

1334752

SERB1
SERPINE1 mRNA-binding protein 1

1

1

Small-scale

0.479

High

1387336

WWTR1
WW domain-containing transcription regulator protein 1

1

2

Small-scale

0.479

High

1387350

PRP19
Pre-mRNA-processing factor 19

1

1

Small-scale

0.479

High

1151613

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.460

High

687477

PTBP1
Polypyrimidine tract-binding protein 1

1

0

Small-scale

0.458

High

772951

MYH9
Myosin-9

1

0

High-throughput

0.458

High

810274

RL3
Large ribosomal subunit protein uL3

1

0

Small-scale

0.458

High

912998

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

0

Small-scale

0.458

High

942119

SOX10
Transcription factor SOX-10

1

0

Small-scale

0.458

High

996285

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.458

High

1103871

ZN211
Zinc finger protein 211

1

0

Small-scale

0.458

High

1387329

PDIP3
Polymerase delta-interacting protein 3

1

0

Small-scale

0.458

High

1387343

SENP1
Sentrin-specific protease 1

1

0

Small-scale

0.458

High

1387353

RTCB
RNA-splicing ligase RtcB homolog

1

0

Small-scale

0.458

High

1387354

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

422843

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

1361993

RFFL
E3 ubiquitin-protein ligase rififylin

1

3

High-throughput

0.457

High

1125182

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

7

High-throughput

0.439

High

1146092

K1H1
Keratin, type I cuticular Ha1

1

1

High-throughput

0.439

High

1230191

K1C40
Keratin, type I cytoskeletal 40

1

1

High-throughput

0.439

High

1387335

TRIM2
Tripartite motif-containing protein 2

1

11

High-throughput

0.439

High

474885

VIME
Vimentin

1

1

Small-scale

0.437

High

1094951

TRAF3
TNF receptor-associated factor 3

1

7

Small-scale

0.437

High

1278065

MAVS
Mitochondrial antiviral-signaling protein

1

1

Small-scale

0.437

High

1387341

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

Small-scale

0.437

High

1387344

RCC2
Protein RCC2

1

2

Small-scale

0.437

High

1209496

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.407

High

1364810

F168A
Protein FAM168A

5

0

High-throughput

0.374

High

1384097

ARRD3
Arrestin domain-containing protein 3

3

0

High-throughput

0.352

High

1199066

PHLA2
Pleckstrin homology-like domain family A member 2

2

0

High-throughput

0.316

High

1381448

PMEPA
Protein TMEPAI

2

0

High-throughput

0.316

High

1386452

PKHB2
Pleckstrin homology domain-containing family B member 2

2

0

High-throughput

0.316

High

1387346

MKRN1
E3 ubiquitin-protein ligase makorin-1

2

0

High-throughput

0.316

High

63866

TPC13
Trafficking protein particle complex subunit 13

1

0

High-throughput

0.279

Low

733413

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

1082559

NEXN
Nexilin

1

0

High-throughput

0.279

Low

1250709

NPSR1
Neuropeptide S receptor

1

0

High-throughput

0.279

Low

1276034

TPC11
Trafficking protein particle complex subunit 11

1

0

High-throughput

0.279

Low

1286674

TPC6B
Trafficking protein particle complex subunit 6B

1

0

High-throughput

0.279

Low

1358061

CPLX3
Complexin-3

1

0

High-throughput

0.279

Low

1387345

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.279

Low

1387351

TPPC4
Trafficking protein particle complex subunit 4

1

0

High-throughput

0.279

Low

1387352

TPPC8
Trafficking protein particle complex subunit 8

1

0

High-throughput

0.279

Low

1220722

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low

1387339

NCOA5
Nuclear receptor coactivator 5

1

0

Small-scale

0.249

Low

1387342

LMBD1
Lysosomal cobalamin transport escort protein LMBD1

1

0

High-throughput

0.249

Low

1387356

PIAS3
E3 SUMO-protein ligase PIAS3

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025