HitPredict

Interactor 1: IMA6 (O15131)
Importin subunit alpha-6 (Karyopherin subunit alpha-5)
Gene: KPNA5

Interactor 2: SPOP (O43791)
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Gene: SPOP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	28805822, 33961781
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 539 Hs			1 374
+	Hs
		213990 IMA7_HUMAN (1-539): 3.03e-148: 438: 84.05		SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00
+	Hs
		214155 IMA5_HUMAN (4-539): 5.49e-143: 424: 79.00		SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00
+	Hs
		168646 IMA6_HUMAN (1-539): 4.99e-148: 437: 100.00		SPOPL_HUMAN (1-374): 1.16e-118: 350: 80.36
+	At
		186838 IMPA1_ARATH (3-539): 3.05e-154: 453: 52.03		BPM3_ARATH (20-365): 1.84e-95: 292: 31.08
+	Hs
		238706 IMA7_HUMAN (1-539): 3.03e-148: 438: 84.05		KLHL7_HUMAN (190-356): 2.89e-61: 208: 30.36
+	Hs
		168654 IMA6_HUMAN (1-539): 4.99e-148: 437: 100.00		KLHL7_HUMAN (190-356): 2.89e-61: 208: 30.36
+	Dm
		283973 O76521_DROME (10-539): 1.47e-144: 428: 59.20		KELC_DROME (148-372): 1.21e-58: 207: 20.44
+	Hs
		238676 IMA7_HUMAN (1-539): 3.03e-148: 438: 84.05		KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92