HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: CSF1R (P07333)
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Gene: CSF1R

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 972
+	Hs
		336052 ZFYV9_HUMAN (155-539): 2.26e-38: 156: 19.00		CSF1R_HUMAN (1-972): 0: 744: 100.00
+	Hs
		169405 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		PGFRB_HUMAN (22-967): 9.71e-179: 550: 31.21
+	Hs
		169424 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		PGFRA_HUMAN (1-910): 8.76e-179: 550: 32.00
+	Hs
		593460 STAM1_HUMAN (4-172): 1.4e-42: 164: 28.40		PGFRA_HUMAN (1-910): 8.76e-179: 550: 32.00
+	Hs
		336063 ZFYV9_HUMAN (155-539): 2.26e-38: 156: 19.00		PGFRA_HUMAN (1-910): 8.76e-179: 550: 32.00
+	Hs
		484170 ZFY16_HUMAN (137-496): 3.67e-38: 155: 17.80		PGFRB_HUMAN (22-967): 9.71e-179: 550: 31.21
+	Hs
		169439 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		FGFR3_HUMAN (13-300): 5.5e-55: 207: 15.02
+	Hs
		169434 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		FGFR2_HUMAN (32-209): 3.5e-27: 121: 15.53
+	Hs
		169413 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		FGFR1_HUMAN (32-209): 5.04e-23: 107: 14.08
+	Hs
		169438 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		FGFR4_HUMAN (32-215): 8.26e-23: 106: 15.71
+	Hs
		650332 STAM1_HUMAN (4-172): 1.4e-42: 164: 28.40		FGFR3_HUMAN (13-300): 5.5e-55: 207: 15.02
+	Hs
		641272 GGA3_HUMAN (6-678): 5.27e-48: 183: 13.96		FGFR2_HUMAN (32-209): 3.5e-27: 121: 15.53
+	Hs
		541721 GGA3_HUMAN (6-678): 5.27e-48: 183: 13.96		FGFR1_HUMAN (32-209): 5.04e-23: 107: 14.08
+	Hs
		648703 GGA3_HUMAN (6-678): 5.27e-48: 183: 13.96		FGFR4_HUMAN (32-215): 8.26e-23: 106: 15.71
+	Hs
		641227 STAM1_HUMAN (4-172): 1.4e-42: 164: 28.40		FGFR2_HUMAN (32-209): 3.5e-27: 121: 15.53
+	Hs
		336068 ZFYV9_HUMAN (155-539): 2.26e-38: 156: 19.00		FGFR2_HUMAN (32-209): 3.5e-27: 121: 15.53
+	Hs
		541620 STAM1_HUMAN (4-172): 1.4e-42: 164: 28.40		FGFR1_HUMAN (32-209): 5.04e-23: 107: 14.08
+	Hs
		648616 STAM1_HUMAN (4-172): 1.4e-42: 164: 28.40		FGFR4_HUMAN (32-215): 8.26e-23: 106: 15.71
+	Hs
		336056 ZFYV9_HUMAN (155-539): 2.26e-38: 156: 19.00		FGFR1_HUMAN (32-209): 5.04e-23: 107: 14.08
+	Hs
		336069 ZFYV9_HUMAN (155-539): 2.26e-38: 156: 19.00		FGFR4_HUMAN (32-215): 8.26e-23: 106: 15.71