HitPredict

Interactor 1: MK13 (O15264)
Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
Gene: MAPK13

Interactor 2: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	19135240
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 365 Hs			1 803
+	Hs
		538216 MK07_HUMAN (11-361): 5.71e-144: 429: 41.39		ENPL_HUMAN (1-803): 0: 1073: 100.00
+	Hs
		538107 CDK2_HUMAN (22-320): 5.41e-146: 416: 37.26		ENPL_HUMAN (1-803): 0: 1073: 100.00
+	Hs
		173815 MK13_HUMAN (1-365): 1.21e-159: 453: 100.00		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		173814 MK13_HUMAN (1-365): 1.21e-159: 453: 100.00		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Mm
		513710 MK07_MOUSE (11-361): 4.71e-144: 429: 41.39		HS90B_MOUSE (75-783): 0: 998: 46.26
+	Rn
		92848 E9PTH2_RAT (11-361): 4.81e-144: 429: 41.39		HS90B_RAT (75-783): 0: 998: 46.26
+	Hs
		438129 MK07_HUMAN (11-361): 5.71e-144: 429: 41.39		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		438208 MK14_HUMAN (1-361): 1.15e-149: 427: 60.22		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431807 MK07_HUMAN (11-361): 5.71e-144: 429: 41.39		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		431896 MK14_HUMAN (1-361): 1.15e-149: 427: 60.22		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		437908 CDK2_HUMAN (22-320): 5.41e-146: 416: 37.26		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		437913 MK03_HUMAN (12-354): 1.25e-144: 415: 43.43		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Rn
		600340 MK03_RAT (15-354): 1.42e-143: 413: 43.23		HS90B_RAT (75-783): 0: 998: 46.26
+	Hs
		431549 CDK2_HUMAN (22-320): 5.41e-146: 416: 37.26		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		431555 MK03_HUMAN (12-354): 1.25e-144: 415: 43.43		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Mm
		432419 MK01_MOUSE (12-355): 3.04e-144: 414: 42.74		HS90A_MOUSE (60-783): 0: 985: 45.28
+	Mm
		432433 MK03_MOUSE (15-354): 1.42e-143: 413: 43.23		HS90A_MOUSE (60-783): 0: 985: 45.28
+	At
		850798 MPK10_ARATH (2-356): 5.22e-145: 417: 41.67		HS903_ARATH (71-783): 0: 955: 49.65
+	Sc
		543393 HOG1_YEAST (3-357): 3.03e-147: 424: 44.10		HSC82_YEAST (72-783): 0: 869: 47.57
+	Sc
		365984 HOG1_YEAST (3-357): 3.03e-147: 424: 44.10		HSP82_YEAST (72-783): 0: 867: 47.17