HitPredict

Interactor 1: ARHGA (O15013)
Rho guanine nucleotide exchange factor 10
Gene: ARHGEF10

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0030036 - actin cytoskeleton organization GO:0051496 - positive regulation of stress fiber assembly GO:0090307 - mitotic spindle assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1369 Hs			1 193
+	Hs
		174233 ARHGA_HUMAN (1-1369): 0: 1204: 100.00		RAC1_HUMAN (1-193): 7e-79: 235: 57.22
+	Hs
		174229 ARHGA_HUMAN (1-1369): 0: 1204: 100.00		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33
+	Hs
		962394 ARHGH_HUMAN (67-1333): 1.59e-180: 588: 16.87		RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00
+	Hs
		955483 FGD4_HUMAN (231-988): 1.48e-117: 387: 14.96		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33
+	Hs
		955059 FGD1_HUMAN (71-989): 2.05e-107: 365: 14.64		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33
+	Hs
		988618 SPT13_HUMAN (177-873): 6.73e-107: 355: 15.70		RAC1_HUMAN (1-193): 7e-79: 235: 57.22
+	Hs
		955486 SPT13_HUMAN (177-873): 6.73e-107: 355: 15.70		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33
+	Hs
		955330 FGD2_HUMAN (344-960): 1.77e-104: 348: 13.80		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33
+	Hs
		962529 ARHG4_HUMAN (139-873): 4.25e-99: 334: 14.85		RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00
+	Hs
		988741 ARHG4_HUMAN (139-873): 4.25e-99: 334: 14.85		RAC1_HUMAN (1-193): 7e-79: 235: 57.22
+	Hs
		176739 MCF2L_HUMAN (192-941): 3.6e-93: 328: 13.89		RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00
+	Hs
		962194 PREX2_HUMAN (399-888): 1.75e-91: 328: 14.40		RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00
+	Hs
		176742 MCF2L_HUMAN (192-941): 3.6e-93: 328: 13.89		RAC1_HUMAN (1-193): 7e-79: 235: 57.22
+	Hs
		988472 PREX2_HUMAN (399-888): 1.75e-91: 328: 14.40		RAC1_HUMAN (1-193): 7e-79: 235: 57.22
+	Hs
		955644 ARHG4_HUMAN (139-873): 4.25e-99: 334: 14.85		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33
+	Hs
		466085 BCR_HUMAN (52-865): 4.97e-92: 327: 17.33		RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71
+	Hs
		1015543 PREX2_HUMAN (399-888): 1.75e-91: 328: 14.40		RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40
+	Hs
		176738 MCF2L_HUMAN (192-941): 3.6e-93: 328: 13.89		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33
+	Hs
		955316 PREX2_HUMAN (399-888): 1.75e-91: 328: 14.40		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33
+	Hs
		539985 BCR_HUMAN (52-865): 4.97e-92: 327: 17.33		CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33