HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	24722339, 30804502, 15832170
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 428 Hs			1 103
+	Mm
		140249 HDAC1_MOUSE (3-385): 0: 588: 62.92		H4_MOUSE (1-103): 1.38e-48: 151: 100.00
+	Hs
		917226 HDAC1_HUMAN (3-385): 0: 588: 62.92		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917682 HDAC2_HUMAN (3-422): 0: 580: 58.63		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Dm
		950398 HDAC1_DROME (3-422): 0: 580: 56.74		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	Mm
		918237 HDAC2_MOUSE (3-422): 0: 578: 58.39		H4_MOUSE (1-103): 1.38e-48: 151: 100.00
+	Sc
		356336 RPD3_YEAST (3-414): 0: 543: 57.07		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	At
		886854 HDA6_ARATH (3-423): 0: 520: 55.32		H4_ARATH (1-103): 3.47e-48: 150: 98.06
+	Sp
		140573 PHD1_SCHPO (3-407): 0: 519: 56.27		H4_SCHPO (18-103): 4.87e-42: 135: 89.54
+	Sc
		356604 HOS2_YEAST (4-420): 1.09e-174: 497: 50.36		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		917872 HDAC8_HUMAN (6-367): 8.28e-143: 414: 41.71		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356643 HDA1_YEAST (4-351): 1.16e-115: 355: 21.56		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		918077 HDAC6_HUMAN (5-320): 3.49e-103: 333: 23.24		H4_HUMAN (1-103): 1.38e-48: 151: 100.00