Protein: HOOK3
Protein Hook homolog 3 (h-hook3) (hHK3)

Gene: HOOK3
Organism: Homo sapiens
Interactions: 206
UniProt ID: Q86VS8

Gene Ontology (top 5):
GO:0000242 - pericentriolar material
GO:0005737 - cytoplasm
GO:0005801 - cis-Golgi network
GO:0005813 - centrosome
GO:0005874 - microtubule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1291582

AKTIP
AKT-interacting protein

8

4

Small-scale

0.972

High

1291602

HOOK1
Protein Hook homolog 1

7

18

Small-scale

0.969

High

1291547

FHI1B
FHF complex subunit HOOK-interacting protein 1B

7

13

Small-scale

0.968

High

1053458

FHI1A
FHF complex subunit HOOK-interacting protein 1A

5

13

High-throughput

0.922

High

1291538

HOOK3
Protein Hook homolog 3

3

18

Small-scale

0.837

High

1290234

FHI2B
FHF complex subunit HOOK-interacting protein 2B

2

13

High-throughput

0.717

High

1291558

HOOK2
Protein Hook homolog 2

1

19

Small-scale

0.713

High

1291608

TN13B
Tumor necrosis factor ligand superfamily member 13B

4

2

High-throughput

0.699

High

1219942

FHI2A
FHF complex subunit HOOK interacting protein 2A

2

13

High-throughput

0.694

High

230545

KIF1C
Kinesin-like protein KIF1C

3

15

Small-scale

0.667

High

1291584

ZC4H2
Zinc finger C4H2 domain-containing protein

3

1

High-throughput

0.667

High

1291592

IFT57
Intraflagellar transport protein 57 homolog

3

0

High-throughput

0.638

High

1092993

CDC16
Cell division cycle protein 16 homolog

2

1

High-throughput

0.628

High

1235376

KLH10
Kelch-like protein 10

2

9

High-throughput

0.628

High

1291593

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

2

14

High-throughput

0.628

High

1191438

GRDN
Girdin

1

17

High-throughput

0.618

High

1291615

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

2

3

High-throughput

0.611

High

881720

FNTB
Protein farnesyltransferase subunit beta

3

2

High-throughput

0.609

High

1291539

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

1

High-throughput

0.609

High

1277569

K1C27
Keratin, type I cytoskeletal 27

3

20

High-throughput

0.607

High

213474

CTIF
CBP80/20-dependent translation initiation factor

3

3

High-throughput

0.596

High

246017

KIF1B
Kinesin-like protein KIF1B

2

15

High-throughput

0.584

High

1145884

RBP1
RalA-binding protein 1

2

14

High-throughput

0.574

High

1233750

CNDH2
Condensin-2 complex subunit H2

2

1

High-throughput

0.574

High

1291609

ADIP
Afadin- and alpha-actinin-binding protein

2

0

High-throughput

0.559

High

566283

K1C13
Keratin, type I cytoskeletal 13

2

20

High-throughput

0.553

High

1291563

PNMA5
Paraneoplastic antigen-like protein 5

2

6

High-throughput

0.553

High

683278

TNR5
Tumor necrosis factor receptor superfamily member 5

2

6

High-throughput

0.549

High

1219506

ANR22
Ankyrin repeat domain-containing protein 22

2

11

High-throughput

0.549

High

174257

ARHGA
Rho guanine nucleotide exchange factor 10

1

20

High-throughput

0.536

High

391324

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

570483

GFAP
Glial fibrillary acidic protein

1

20

High-throughput

0.536

High

721029

CLIP1
CAP-Gly domain-containing linker protein 1

1

17

High-throughput

0.536

High

730018

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

920706

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

1

High-throughput

0.536

High

928198

HAP1
Huntingtin-associated protein 1

1

19

High-throughput

0.536

High

997408

TBB4B
Tubulin beta-4B chain

1

1

High-throughput

0.536

High

1113582

CUL3
Cullin-3

1

20

High-throughput

0.536

High

1152136

MARE1
Microtubule-associated protein RP/EB family member 1

1

7

High-throughput

0.536

High

1218051

CBPC6
Cytosolic carboxypeptidase 6

1

1

High-throughput

0.536

High

1291540

SKAP1
Src kinase-associated phosphoprotein 1

1

20

High-throughput

0.536

High

1291557

TRI52
E3 ubiquitin-protein ligase TRIM52

1

14

High-throughput

0.536

High

1291569

CAB45
45 kDa calcium-binding protein

1

7

High-throughput

0.536

High

1291572

FEM1A
Protein fem-1 homolog A

1

15

High-throughput

0.536

High

1291575

DUS16
Dual specificity protein phosphatase 16

1

10

High-throughput

0.536

High

1291610

KLH20
Kelch-like protein 20

1

8

High-throughput

0.536

High

1123699

DCTN1
Dynactin subunit 1

1

18

High-throughput

0.515

High

1123963

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

9

High-throughput

0.515

High

530036

TAU
Microtubule-associated protein tau

1

11

Small-scale

0.501

High

300403

KRT34
Keratin, type I cuticular Ha4

1

20

High-throughput

0.489

High

300667

KRT37
Keratin, type I cuticular Ha7

1

20

High-throughput

0.489

High

848514

MAGA8
Melanoma-associated antigen 8

1

7

High-throughput

0.489

High

922827

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

7

High-throughput

0.489

High

1041773

PPARD
Peroxisome proliferator-activated receptor delta

1

14

High-throughput

0.489

High

1101566

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

7

High-throughput

0.489

High

1146014

K1H1
Keratin, type I cuticular Ha1

1

20

High-throughput

0.489

High

1291545

FAM9C
Protein FAM9C

1

2

High-throughput

0.489

High

1291546

SYCE1
Synaptonemal complex central element protein 1

1

3

High-throughput

0.489

High

1291555

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

1

1

High-throughput

0.489

High

1291606

AP4E1
AP-4 complex subunit epsilon-1

1

8

Small-scale

0.489

High

893984

MEOX2
Homeobox protein MOX-2

1

7

High-throughput

0.481

High

1291585

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.481

High

67782

TBKB1
TANK-binding kinase 1-binding protein 1

1

6

High-throughput

0.479

High

143655

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

8

High-throughput

0.479

High

159731

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

19

High-throughput

0.479

High

177391

ARHGB
Rho guanine nucleotide exchange factor 11

1

14

High-throughput

0.479

High

210581

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

3

High-throughput

0.479

High

214595

WDR62
WD repeat-containing protein 62

1

11

High-throughput

0.479

High

215437

TPD54
Tumor protein D54

1

1

High-throughput

0.479

High

244589

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

10

High-throughput

0.479

High

255445

SNX2
Sorting nexin-2

1

2

High-throughput

0.479

High

322421

HAUS5
HAUS augmin-like complex subunit 5

1

2

High-throughput

0.479

High

414133

P53
Cellular tumor antigen p53

1

7

High-throughput

0.479

High

537450

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.479

High

547163

PYC
Pyruvate carboxylase, mitochondrial

1

8

High-throughput

0.479

High

551138

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.479

High

573157

KPYM
Pyruvate kinase PKM

1

1

High-throughput

0.479

High

626273

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

19

High-throughput

0.479

High

668649

APC
Adenomatous polyposis coli protein

1

18

High-throughput

0.479

High

691198

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

749955

KINH
Kinesin-1 heavy chain

1

9

High-throughput

0.479

High

773223

MYH10
Myosin-10

1

18

High-throughput

0.479

High

888794

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

9

Small-scale

0.479

High

902935

DUS3
Dual specificity protein phosphatase 3

1

11

High-throughput

0.479

High

936657

BRPF1
Peregrin

1

10

High-throughput

0.479

High

936798

NP1L1
Nucleosome assembly protein 1-like 1

1

3

High-throughput

0.479

High

993234

ACTG
Actin, cytoplasmic 2

1

20

High-throughput

0.479

High

1045465

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

1058877

ZO1
Tight junction protein 1

1

15

High-throughput

0.479

High

1085185

WASC5
WASH complex subunit 5

1

1

High-throughput

0.479

High

1104209

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

7

High-throughput

0.479

High

1143390

PCM1
Pericentriolar material 1 protein

1

3

High-throughput

0.479

High

1225369

WAC2A
WASH complex subunit 2A

1

2

High-throughput

0.479

High

1241088

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

11

High-throughput

0.479

High

1254472

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1289938

LUZP1
Leucine zipper protein 1

1

20

High-throughput

0.479

High

1291541

CEP97
Centrosomal protein of 97 kDa

1

6

High-throughput

0.479

High

1291542

MA7D3
MAP7 domain-containing protein 3

1

4

High-throughput

0.479

High

1291550

GOGA5
Golgin subfamily A member 5

1

17

High-throughput

0.479

High

1291551

ALMS1
Centrosome-associated protein ALMS1

1

8

High-throughput

0.479

High

1291553

DLG5
Disks large homolog 5

1

16

High-throughput

0.479

High

1291554

PDC6I
Programmed cell death 6-interacting protein

1

16

High-throughput

0.479

High

1291560

CEP63
Centrosomal protein of 63 kDa

1

17

High-throughput

0.479

High

1291562

RBM14
RNA-binding protein 14

1

4

High-throughput

0.479

High

1291564

SPAG5
Sperm-associated antigen 5

1

19

High-throughput

0.479

High

1291566

NP1L4
Nucleosome assembly protein 1-like 4

1

3

High-throughput

0.479

High

1291568

COR1B
Coronin-1B

1

13

High-throughput

0.479

High

1291573

TBB2B
Tubulin beta-2B chain

1

1

High-throughput

0.479

High

1291574

IFT27
Intraflagellar transport protein 27 homolog

1

10

High-throughput

0.479

High

1291578

KLC2
Kinesin light chain 2

1

10

High-throughput

0.479

High

1291579

CCDC8
Coiled-coil domain-containing protein 8

1

6

High-throughput

0.479

High

1291580

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

2

Small-scale

0.479

High

1291583

Q9HCK3
KIAA1569 protein

1

1

High-throughput

0.479

High

1291588

KLC4
Kinesin light chain 4

1

10

High-throughput

0.479

High

1291594

ABI2
Abl interactor 2

1

19

High-throughput

0.479

High

1291597

BCCIP
BRCA2 and CDKN1A-interacting protein

1

1

High-throughput

0.479

High

1291598

CING
Cingulin

1

17

High-throughput

0.479

High

1291599

AASS
Alpha-aminoadipic semialdehyde synthase, mitochondrial

1

2

High-throughput

0.479

High

1291601

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

1291604

MYO6
Unconventional myosin-VI

1

16

High-throughput

0.479

High

1291613

WAC2C
WASH complex subunit 2C

1

2

High-throughput

0.479

High

640682

MSRE
Macrophage scavenger receptor types I and II

1

9

Small-scale

0.470

High

1232436

Q6FHY5
MEOX2 protein

1

6

High-throughput

0.470

High

897543

BPL1
Biotin--protein ligase

1

0

High-throughput

0.458

High

1198444

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.458

High

1248011

AFTIN
Aftiphilin

1

0

High-throughput

0.458

High

1291577

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.458

High

1291591

BSDC1
BSD domain-containing protein 1

1

0

High-throughput

0.458

High

1291605

SYNRG
Synergin gamma

1

0

High-throughput

0.458

High

58853

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

4

High-throughput

0.445

High

339374

ETHE1
Persulfide dioxygenase ETHE1, mitochondrial

1

6

High-throughput

0.445

High

934816

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.445

High

1210897

CE170
Centrosomal protein of 170 kDa

1

14

High-throughput

0.445

High

106206

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

139914

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

144290

ACACB
Acetyl-CoA carboxylase 2

1

8

High-throughput

0.437

High

177252

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

16

High-throughput

0.437

High

218404

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.437

High

228608

STRN
Striatin

1

11

High-throughput

0.437

High

262096

NBN
Nibrin

1

1

High-throughput

0.437

High

269026

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

1

High-throughput

0.437

High

271165

COBL
Protein cordon-bleu

1

3

High-throughput

0.437

High

273686

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

7

High-throughput

0.437

High

286236

CSDE1
Cold shock domain-containing protein E1

1

1

High-throughput

0.437

High

300009

CBPD
Carboxypeptidase D

1

4

High-throughput

0.437

High

361540

CERU
Ceruloplasmin

1

1

High-throughput

0.437

High

412196

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.437

High

425821

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

8

High-throughput

0.437

High

425925

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

5

High-throughput

0.437

High

447800

TPM3
Tropomyosin alpha-3 chain

1

19

High-throughput

0.437

High

475619

K1C19
Keratin, type I cytoskeletal 19

1

20

High-throughput

0.437

High

540046

BCR
Breakpoint cluster region protein

1

20

High-throughput

0.437

High

548534

MPRI
Cation-independent mannose-6-phosphate receptor

1

3

High-throughput

0.437

High

729340

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

4

High-throughput

0.437

High

755974

MCM5
DNA replication licensing factor MCM5

1

8

High-throughput

0.437

High

867257

CAPZB
F-actin-capping protein subunit beta

1

7

High-throughput

0.437

High

915129

CAZA1
F-actin-capping protein subunit alpha-1

1

8

High-throughput

0.437

High

952595

MYL6
Myosin light polypeptide 6

1

20

High-throughput

0.437

High

1094208

ACACA
Acetyl-CoA carboxylase 1

1

8

High-throughput

0.437

High

1124993

RCN2
Reticulocalbin-2

1

7

High-throughput

0.437

High

1135440

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

12

High-throughput

0.437

High

1143182

PLEC
Plectin

1

20

High-throughput

0.437

High

1178773

AAK1
AP2-associated protein kinase 1

1

14

High-throughput

0.437

High

1180284

ATG2A
Autophagy-related protein 2 homolog A

1

3

High-throughput

0.437

High

1203566

ZN326
DBIRD complex subunit ZNF326

1

1

High-throughput

0.437

High

1204752

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

3

High-throughput

0.437

High

1225943

F91A1
Protein FAM91A1

1

1

High-throughput

0.437

High

1247864

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

3

High-throughput

0.437

High

1287089

PATL1
Protein PAT1 homolog 1

1

3

High-throughput

0.437

High

1291543

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

7

High-throughput

0.437

High

1291548

KRI1
Protein KRI1 homolog

1

2

High-throughput

0.437

High

1291549

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

16

High-throughput

0.437

High

1291556

RAD50
DNA repair protein RAD50

1

18

High-throughput

0.437

High

1291565

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

8

High-throughput

0.437

High

1291567

H2B1M
Histone H2B type 1-M

1

20

High-throughput

0.437

High

1291570

GPTC1
G patch domain-containing protein 1

1

8

High-throughput

0.437

High

1291571

WDR83
WD repeat domain-containing protein 83

1

9

High-throughput

0.437

High

1291576

BACH2
Transcription regulator protein BACH2

1

11

High-throughput

0.437

High

1291581

OSBL3
Oxysterol-binding protein-related protein 3

1

1

High-throughput

0.437

High

1291586

VPS45
Vacuolar protein sorting-associated protein 45

1

5

High-throughput

0.437

High

1291587

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

2

High-throughput

0.437

High

1291589

TBC23
TBC1 domain family member 23

1

3

High-throughput

0.437

High

1291590

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

1

High-throughput

0.437

High

1291596

SEP10
Septin-10

1

4

High-throughput

0.437

High

1291600

ZO2
Tight junction protein 2

1

13

High-throughput

0.437

High

1291603

RAB21
Ras-related protein Rab-21

1

14

High-throughput

0.437

High

1291607

PHF8
Histone lysine demethylase PHF8

1

4

High-throughput

0.437

High

1291614

HYOU1
Hypoxia up-regulated protein 1

1

9

High-throughput

0.437

High

1291616

WASF2
Actin-binding protein WASF2

1

6

High-throughput

0.437

High

50608

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.407

High

844818

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.407

High

1167070

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

3

High-throughput

0.407

High

1240891

S27A4
Long-chain fatty acid transport protein 4

1

7

High-throughput

0.407

High

1243621

S27A1
Long-chain fatty acid transport protein 1

1

7

High-throughput

0.407

High

50915

SYCE3
Synaptonemal complex central element protein 3

2

0

High-throughput

0.328

High

1248532

LCTL
Lactase-like protein

1

0

High-throughput

0.279

Low

1291561

TMM74
Transmembrane protein 74

1

0

High-throughput

0.279

Low

484589

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

1054305

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

High-throughput

0.249

Low

1291544

K319L
Dyslexia-associated protein KIAA0319-like protein

1

0

High-throughput

0.249

Low

1291559

LTV1
Protein LTV1 homolog

1

0

High-throughput

0.249

Low

1291595

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.249

Low

1291611

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

0

High-throughput

0.249

Low

1291612

HBS1L
HBS1-like protein

1

0

High-throughput

0.249

Low

1291552

MO2R1
Cell surface glycoprotein CD200 receptor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025