HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: TAB2 (Q9NYJ8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
Gene: TAB2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	12150997
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 428 Hs			1 693
+	Hs
		1038759 HDAC1_HUMAN (3-385): 0: 588: 62.92		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Mm
		292413 HDAC3_MOUSE (1-428): 0: 601: 99.77		SMCA4_MOUSE (201-665): 3.01e-44: 173: 11.52
+	Mm
		140261 HDAC1_MOUSE (3-385): 0: 588: 62.92		SMCA4_MOUSE (201-665): 3.01e-44: 173: 11.52
+	Mm
		936385 HDAC2_MOUSE (3-422): 0: 578: 58.39		SMCA4_MOUSE (201-665): 3.01e-44: 173: 11.52
+	Dm
		631303 Q7KTS4_DROME (3-427): 0: 550: 65.67		BRM_DROME (165-665): 1e-43: 172: 12.74
+	Hs
		177241 HDAC3_HUMAN (1-428): 0: 600: 100.00		SMCA4_HUMAN (111-415): 6.46e-09: 61.7: 8.81
+	Hs
		846768 HDAC1_HUMAN (3-385): 0: 588: 62.92		SMCA2_HUMAN (127-396): 1.06e-10: 67.5: 10.22
+	Hs
		257609 HDAC1_HUMAN (3-385): 0: 588: 62.92		ANR17_HUMAN (117-519): 7.6e-10: 64.7: 11.54
+	Hs
		203227 HDAC1_HUMAN (3-385): 0: 588: 62.92		SYNJ1_HUMAN (303-658): 3.22e-09: 62.5: 9.55
+	Hs
		846962 HDAC1_HUMAN (3-385): 0: 588: 62.92		SMCA4_HUMAN (111-415): 6.46e-09: 61.7: 8.81
+	Hs
		846833 HDAC2_HUMAN (3-422): 0: 580: 58.63		SMCA2_HUMAN (127-396): 1.06e-10: 67.5: 10.22
+	Hs
		257678 HDAC2_HUMAN (3-422): 0: 580: 58.63		ANR17_HUMAN (117-519): 7.6e-10: 64.7: 11.54
+	Hs
		847037 HDAC2_HUMAN (3-422): 0: 580: 58.63		SMCA4_HUMAN (111-415): 6.46e-09: 61.7: 8.81
+	Hs
		980012 HDAC6_HUMAN (5-320): 3.49e-103: 333: 23.24		IF4G1_HUMAN (71-521): 3.73e-21: 101: 8.28