Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4
Interactor 2: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.99 | 0.60 | 0.773 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 24659749, 26186194, 25464845, 25609649, 26148237, 25825738, 27114532, 26876197, 28487147, 25961923, 29523541, 22745160, 30598450, 28205554, 31152661, 30832340, 9226370, 33961781, 16227609, 20174603 and 48 others
more... |
| Identification Methods | pull down, affinity chromatography technology, protein complementation assay, unspecified method, fluorescent resonance energy transfer, x-ray crystallography, enzymatic study, isothermal titration calorimetry, anti bait coimmunoprecipitation, fluorescence polarization spectroscopy and 4 others
more... |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0008285 - negative regulation of cell population proliferation and 9 others more... |
| Homologous interactions | 10 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
