HitPredict

Interactor 1: MDM2 (P23804)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: P73 (Q9JJP2)
Tumor protein p73 (p53-like transcription factor) (p53-related protein)
Gene: Tp73

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20921405
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002039 - p53 binding GO:0005634 - nucleus GO:0009410 - response to xenobiotic stimulus GO:0010468 - regulation of gene expression
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 489 Mm			1 631
+	Hs
		186733 MDM2_HUMAN (1-488): 0: 636: 80.85		P73_HUMAN (1-631): 0: 945: 88.30
+	Hs
		179651 MDM4_HUMAN (4-488): 0: 560: 31.61		P73_HUMAN (1-631): 0: 945: 88.30
+	Hs
		1028391 MDM2_HUMAN (1-488): 0: 636: 80.85		P63_HUMAN (1-624): 0: 807: 53.79
+	Hs
		179742 MDM4_HUMAN (4-488): 0: 560: 31.61		P63_HUMAN (1-624): 0: 807: 53.79
+	Mm
		382448 MDM2_MOUSE (1-489): 0: 673: 100.00		P53_MOUSE (8-392): 2.17e-162: 472: 40.00
+	Rn
		93110 D3ZVH5_RAT (1-489): 0: 633: 85.28		P53_RAT (1-385): 1.66e-162: 472: 42.34
+	Hs
		413638 MDM2_HUMAN (1-488): 0: 636: 80.85		P53_HUMAN (8-392): 6.34e-150: 440: 38.92
+	Mm
		205232 MDM4_MOUSE (4-488): 0: 571: 31.69		P53_MOUSE (8-392): 2.17e-162: 472: 40.00
+	Hs
		116929 J3KN53_HUMAN (1-488): 0: 602: 76.21		P53_HUMAN (8-392): 6.34e-150: 440: 38.92
+	Hs
		179660 MDM4_HUMAN (4-488): 0: 560: 31.61		P53_HUMAN (8-392): 6.34e-150: 440: 38.92