HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.80	0.741

Property	Details
Experiments	32700452, 29991678, 9727029
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 1367
+	Hs
		435801 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		IGF1R_HUMAN (1-1367): 0: 1387: 100.00
+	Hs
		146583 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		IGF1R_HUMAN (1-1367): 0: 1387: 100.00
+	Hs
		146667 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Mm
		193338 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		INSR_MOUSE (20-1365): 0: 1219: 56.40
+	Hs
		181763 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Hs
		411523 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Hs
		147471 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		INSR_HUMAN (32-1365): 0: 1219: 56.54
+	Hs
		147489 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		EPHA2_HUMAN (653-1304): 6.11e-163: 516: 23.93
+	Hs
		181899 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12
+	Hs
		256861 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12
+	Hs
		1356638 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12
+	Hs
		181803 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10
+	Dm
		526800 Q8INY1_DROME (26-210): 6.61e-43: 154: 23.00		7LESS_DROME (993-1259): 6.81e-67: 252: 48.73
+	Hs
		181796 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FGFR3_HUMAN (972-1266): 2.05e-63: 234: 38.44
+	Hs
		146579 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61
+	Hs
		147484 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		FGFR3_HUMAN (972-1266): 2.05e-63: 234: 38.44
+	Hs
		256849 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88
+	Hs
		602023 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88
+	Hs
		147483 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88
+	Hs
		445884 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ROS1_HUMAN (691-919): 7.36e-11: 69.4: 17.47