HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: EPHA6 (Q9UF33)
Ephrin type-A receptor 6 (EC 2.7.10.1) (EPH homology kinase 2) (EHK-2) (EPH-like kinase 12) (EK12)
Gene: EPHA6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38334954
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~PK_Tyr_Ser-Thr
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 1036
+	Hs
		468218 HS90B_HUMAN (1-724): 0: 1083: 100.00		EPHA4_HUMAN (15-1036): 0: 1184: 56.88
+	Hs
		468217 HS90B_HUMAN (1-724): 0: 1083: 100.00		EPHB1_HUMAN (33-1033): 0: 1171: 51.53
+	Hs
		468100 HS90B_HUMAN (1-724): 0: 1083: 100.00		EPHA2_HUMAN (31-1036): 0: 1054: 46.59
+	Hs
		468066 HS90B_HUMAN (1-724): 0: 1083: 100.00		EPHA1_HUMAN (23-1023): 0: 943: 40.33
+	Hs
		181772 HS90B_HUMAN (1-724): 0: 1083: 100.00		EPHB6_HUMAN (17-1019): 0: 912: 37.20
+	Hs
		181771 HS90A_HUMAN (1-724): 0: 1069: 85.25		EPHB6_HUMAN (17-1019): 0: 912: 37.20
+	Hs
		468312 HS90B_HUMAN (1-724): 0: 1083: 100.00		MERTK_HUMAN (275-977): 2.1e-156: 491: 20.82
+	Hs
		468105 HS90B_HUMAN (1-724): 0: 1083: 100.00		UFO_HUMAN (297-993): 3e-155: 484: 22.18
+	Hs
		468073 HS90B_HUMAN (1-724): 0: 1083: 100.00		FGFR3_HUMAN (382-986): 1.52e-151: 472: 19.91
+	Hs
		468004 HS90B_HUMAN (1-724): 0: 1083: 100.00		FGFR1_HUMAN (382-968): 4.18e-148: 463: 20.35
+	Hs
		468294 HS90B_HUMAN (1-724): 0: 1083: 100.00		TYRO3_HUMAN (295-967): 4.21e-147: 463: 20.83
+	Hs
		465366 HS90B_HUMAN (1-724): 0: 1083: 100.00		IGF1R_HUMAN (388-932): 6.13e-132: 434: 26.92
+	Hs
		461043 HS90A_HUMAN (1-724): 0: 1069: 85.25		IGF1R_HUMAN (388-932): 6.13e-132: 434: 26.92
+	Hs
		468290 HS90B_HUMAN (1-724): 0: 1083: 100.00		FAK1_HUMAN (608-939): 4.28e-59: 223: 36.45
+	Hs
		462949 HS90B_HUMAN (1-724): 0: 1083: 100.00		YES_HUMAN (623-931): 5.62e-60: 217: 40.65
+	Hs
		440303 HS90B_HUMAN (1-724): 0: 1083: 100.00		FYN_HUMAN (625-931): 3.79e-59: 214: 37.99
+	Hs
		468013 HS90B_HUMAN (1-724): 0: 1083: 100.00		SRC_HUMAN (623-931): 3.43e-59: 214: 40.32
+	Hs
		461038 HS90A_HUMAN (1-724): 0: 1069: 85.25		YES_HUMAN (623-931): 5.62e-60: 217: 40.65
+	Hs
		440299 HS90A_HUMAN (1-724): 0: 1069: 85.25		FYN_HUMAN (625-931): 3.79e-59: 214: 37.99
+	Hs
		468023 HS90B_HUMAN (1-724): 0: 1083: 100.00		INSRR_HUMAN (318-486): 7.87e-10: 65.4: 17.84