HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	29991678
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 894
+	Hs
		146597 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		EPHA2_HUMAN (3-837): 0: 604: 19.66
+	Hs
		147489 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		EPHA2_HUMAN (3-837): 0: 604: 19.66
+	Hs
		181846 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		TIE2_HUMAN (16-809): 3.58e-164: 510: 23.90
+	Hs
		146667 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		INSR_HUMAN (272-851): 1.65e-136: 443: 27.97
+	Hs
		181763 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		INSR_HUMAN (272-851): 1.65e-136: 443: 27.97
+	Mm
		193338 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		INSR_MOUSE (232-851): 2.75e-135: 439: 26.37
+	Hs
		411523 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		INSR_HUMAN (272-851): 1.65e-136: 443: 27.97
+	Hs
		147471 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		INSR_HUMAN (272-851): 1.65e-136: 443: 27.97
+	Hs
		181774 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		256845 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		441580 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		146584 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		147476 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		MET_HUMAN (536-799): 3.42e-66: 243: 45.90
+	Hs
		181850 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FAK1_HUMAN (527-851): 1.72e-56: 213: 36.83
+	Hs
		445884 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		ROS1_HUMAN (284-804): 1.68e-56: 214: 31.27
+	Hs
		181796 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FGFR3_HUMAN (2-135): 5.06e-15: 81.7: 14.29
+	Hs
		181772 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		IGF1R_HUMAN (234-385): 4.65e-12: 72.4: 18.07
+	Hs
		147484 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		FGFR3_HUMAN (2-135): 5.06e-15: 81.7: 14.29
+	Hs
		435801 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		IGF1R_HUMAN (234-385): 4.65e-12: 72.4: 18.07
+	Hs
		146583 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		IGF1R_HUMAN (234-385): 4.65e-12: 72.4: 18.07