HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: UNC5B (Q8IZJ1)
Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1)
Gene: UNC5B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~fn3
Common GO terms	GO:0001525 - angiogenesis GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 945
+	Hs
		1147372 EPHA7_HUMAN (4-974): 0: 1120: 50.15		UNC5B_HUMAN (1-945): 0: 946: 100.00
+	Hs
		931868 EPHA5_HUMAN (11-976): 0: 1115: 51.34		UNC5B_HUMAN (1-945): 0: 946: 100.00
+	Hs
		932098 EPHA4_HUMAN (1-974): 0: 1110: 50.35		UNC5B_HUMAN (1-945): 0: 946: 100.00
+	Hs
		710861 EPHB2_HUMAN (28-973): 0: 1077: 48.29		UNC5B_HUMAN (1-945): 0: 946: 100.00
+	Hs
		710730 EPHA8_HUMAN (28-975): 0: 1037: 46.72		UNC5B_HUMAN (1-945): 0: 946: 100.00
+	Hs
		328779 EPHA2_HUMAN (1-976): 0: 1124: 100.00		UNC5C_HUMAN (34-944): 0: 850: 63.78
+	Hs
		181803 EPHB6_HUMAN (28-962): 0: 869: 37.40		UNC5B_HUMAN (1-945): 0: 946: 100.00
+	Hs
		439783 INSR_HUMAN (281-911): 2.91e-136: 444: 24.78		UNC5B_HUMAN (1-945): 0: 946: 100.00
+	Hs
		465575 IGF1R_HUMAN (393-877): 1.45e-133: 437: 29.90		UNC5B_HUMAN (1-945): 0: 946: 100.00
+	Hs
		710600 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ROBO1_HUMAN (2-291): 4.46e-42: 169: 18.18
+	Hs
		710503 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ROBO2_HUMAN (2-244): 1.37e-38: 158: 16.47
+	Hs
		463641 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		UNC5B_HUMAN (1-945): 0: 946: 100.00
+	Ce
		109605 VAB1_CAEEL (3-953): 0: 749: 29.00		SAX3_CAEEL (2-246): 6.55e-22: 104: 10.94
+	Hs
		439776 INSR_HUMAN (281-911): 2.91e-136: 444: 24.78		UN5CL_HUMAN (492-931): 2.43e-116: 367: 23.73
+	Hs
		465567 IGF1R_HUMAN (393-877): 1.45e-133: 437: 29.90		UN5CL_HUMAN (492-931): 2.43e-116: 367: 23.73
+	Hs
		720200 UFO_HUMAN (294-911): 1.96e-144: 454: 24.15		ZO1_HUMAN (413-656): 5.95e-48: 188: 23.70
+	Hs
		463875 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		ROBO1_HUMAN (2-291): 4.46e-42: 169: 18.18
+	Hs
		463779 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		ROBO2_HUMAN (2-244): 1.37e-38: 158: 16.47
+	Hs
		463561 LYN_HUMAN (607-879): 2.07e-64: 228: 42.91		SDK2_HUMAN (12-282): 1.67e-22: 106: 9.54