HitPredict

Interactor 1: CFLAR (O15519)
CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
Gene: CFLAR

Interactor 2: TNF10 (P50591)
Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)
Gene: TNFSF10

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 0.60 0.714

The method score is based on:

Property Details
Experiments 19432816, 22266862, 21822306, 20097879, 21525171, 23678861
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0006915 - apoptotic process
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 480
Hs

1 281
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Service provided by Combinatics, Japan

Last updated: 11Aug2025