Protein: SMUF2
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)

Gene: SMUF2, SMURF2
Organism: Homo sapiens
Interactions: 179
UniProt ID: Q9HAU4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1334869

SMUF2
E3 ubiquitin-protein ligase SMURF2

17

15

Small-scale

0.986

High

932579

UB2L3
Ubiquitin-conjugating enzyme E2 L3

11

20

Small-scale

0.978

High

895918

UB2D3
Ubiquitin-conjugating enzyme E2 D3

11

20

Small-scale

0.976

High

476403

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

8

20

Small-scale

0.963

High

1334870

SMUF1
E3 ubiquitin-protein ligase SMURF1

5

16

Small-scale

0.922

High

849451

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

20

Small-scale

0.914

High

808276

NEDD4
E3 ubiquitin-protein ligase NEDD4

4

18

Small-scale

0.899

High

475196

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

20

Small-scale

0.778

High

919867

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.778

High

167394

SMAD7
Mothers against decapentaplegic homolog 7

19

20

Small-scale

0.766

High

1078667

SMAD2
Mothers against decapentaplegic homolog 2

14

20

Small-scale

0.762

High

950287

SMAD3
Mothers against decapentaplegic homolog 3

13

20

Small-scale

0.761

High

1078760

SMAD1
Mothers against decapentaplegic homolog 1

11

20

Small-scale

0.759

High

738578

TGFR1
TGF-beta receptor type-1

8

19

Small-scale

0.741

High

1334883

RNF11
RING finger protein 11

6

14

Small-scale

0.740

High

1079607

NEDD8
NEDD8

1

19

Small-scale

0.724

High

1305886

SMAD5
Mothers against decapentaplegic homolog 5

5

20

Small-scale

0.719

High

1313360

TRAF4
TNF receptor-associated factor 4

4

15

Small-scale

0.707

High

900923

RHOA
Transforming protein RhoA

4

20

Small-scale

0.686

High

338999

EGFR
Epidermal growth factor receptor

3

20

Small-scale

0.678

High

1022690

RHG05
Rho GTPase-activating protein 5

3

7

High-throughput

0.674

High

170568

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

12

High-throughput

0.667

High

206976

SMAD6
Mothers against decapentaplegic homolog 6

3

20

Small-scale

0.650

High

1046760

KLF5
Krueppel-like factor 5

2

10

Small-scale

0.643

High

740064

TGFR2
TGF-beta receptor type-2

3

19

Small-scale

0.640

High

455889

PARP1
Poly [ADP-ribose] polymerase 1

2

7

Small-scale

0.634

High

632917

TYY1
Transcriptional repressor protein YY1

2

4

Small-scale

0.624

High

780988

ID1
DNA-binding protein inhibitor ID-1

2

2

Small-scale

0.624

High

1138223

BRE1A
E3 ubiquitin-protein ligase BRE1A

2

4

Small-scale

0.624

High

1289443

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

6

Small-scale

0.624

High

1334885

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

6

Small-scale

0.624

High

1065189

DAZP2
DAZ-associated protein 2

2

2

Small-scale

0.620

High

228743

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

506664

BCR
Breakpoint cluster region protein

1

9

Small-scale

0.618

High

542919

BRAF
Serine/threonine-protein kinase B-raf

1

13

Small-scale

0.618

High

808942

YAP1
Transcriptional coactivator YAP1

1

17

Small-scale

0.618

High

896227

UBC12
NEDD8-conjugating enzyme Ubc12

1

20

Small-scale

0.618

High

924414

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

17

Small-scale

0.618

High

930397

UBC9
SUMO-conjugating enzyme UBC9

1

20

Small-scale

0.618

High

1334880

HERC5
E3 ISG15--protein ligase HERC5

1

15

Small-scale

0.618

High

1334875

CUED1
CUE domain-containing protein 1

3

6

Small-scale

0.607

High

970647

SEMG2
Semenogelin-2

2

0

High-throughput

0.602

High

1229725

SPART
Spartin

2

10

Small-scale

0.595

High

1330593

FXL15
F-box/LRR-repeat protein 15

1

10

Small-scale

0.589

High

836001

GSK3B
Glycogen synthase kinase-3 beta

2

3

Small-scale

0.584

High

1035596

SMAD4
Mothers against decapentaplegic homolog 4

2

20

Small-scale

0.584

High

1080361

EZH2
Histone-lysine N-methyltransferase EZH2

2

5

Small-scale

0.584

High

360429

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

6

Small-scale

0.578

High

509131

TOP2A
DNA topoisomerase 2-alpha

1

4

Small-scale

0.578

High

865086

TTC3
E3 ubiquitin-protein ligase TTC3

1

20

Small-scale

0.578

High

877365

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

11

Small-scale

0.578

High

1029891

TIF1B
Transcription intermediary factor 1-beta

1

9

Small-scale

0.578

High

1306986

ANM1
Protein arginine N-methyltransferase 1

1

6

Small-scale

0.578

High

1334877

LMCD1
LIM and cysteine-rich domains protein 1

2

11

Small-scale

0.576

High

1292822

SYMM
Methionine--tRNA ligase, mitochondrial

2

6

High-throughput

0.574

High

163304

XPO1
Exportin-1

1

9

Small-scale

0.561

High

170722

AXIN1
Axin-1

1

1

Small-scale

0.561

High

383984

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.561

High

971141

ID3
DNA-binding protein inhibitor ID-3

1

2

Small-scale

0.561

High

991147

PDE4B
3',5'-cyclic-AMP phosphodiesterase 4B

1

5

Small-scale

0.561

High

1019448

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

2

Small-scale

0.561

High

1026363

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

Small-scale

0.561

High

1190096

MAVS
Mitochondrial antiviral-signaling protein

1

12

Small-scale

0.561

High

1263850

CNKR2
Connector enhancer of kinase suppressor of ras 2

1

7

Small-scale

0.561

High

1283851

FUBP1
Far upstream element-binding protein 1

1

11

Small-scale

0.561

High

1334874

RNF12
E3 ubiquitin-protein ligase RLIM

1

6

Small-scale

0.561

High

1334881

FBW1A
F-box/WD repeat-containing protein 1A

1

6

Small-scale

0.561

High

1262911

RT4I1
Reticulon-4-interacting protein 1, mitochondrial

2

7

High-throughput

0.553

High

1031615

ATM
Serine-protein kinase ATM

1

4

Small-scale

0.536

High

131844

KRIT1
Krev interaction trapped protein 1

1

12

High-throughput

0.536

High

445542

RSSA
Small ribosomal subunit protein uS2

1

5

High-throughput

0.536

High

550964

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.536

High

759836

RS19
Small ribosomal subunit protein eS19

1

4

High-throughput

0.536

High

254312

AOC2
Amine oxidase [copper-containing] 2

1

0

High-throughput

0.513

High

317766

STABP
STAM-binding protein

1

0

Small-scale

0.513

High

1294776

PAWR
PRKC apoptosis WT1 regulator protein

1

0

High-throughput

0.513

High

173395

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

2

High-throughput

0.508

High

261331

FLNB
Filamin-B

1

12

High-throughput

0.508

High

442507

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.508

High

957214

DAB2
Disabled homolog 2

1

4

High-throughput

0.508

High

1039518

LAPM5
Lysosomal-associated transmembrane protein 5

1

7

High-throughput

0.508

High

1063121

ABRX2
BRISC complex subunit Abraxas 2

1

3

High-throughput

0.508

High

1073730

SF3A2
Splicing factor 3A subunit 2

1

5

High-throughput

0.508

High

1169192

RN111
E3 ubiquitin-protein ligase Arkadia

1

5

High-throughput

0.508

High

1330179

TXNIP
Thioredoxin-interacting protein

1

20

High-throughput

0.508

High

1334886

TNPO3
Transportin-3

1

8

High-throughput

0.508

High

152750

ITBP1
Integrin beta-1-binding protein 1

1

1

Small-scale

0.501

High

560851

PDE6A
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

1

5

High-throughput

0.501

High

606310

CADH3
Cadherin-3

1

1

High-throughput

0.501

High

723851

SCN1A
Sodium channel protein type 1 subunit alpha

1

20

High-throughput

0.501

High

742540

SYUA
Alpha-synuclein

1

4

Small-scale

0.501

High

1047430

RUNX2
Runt-related transcription factor 2

1

11

Small-scale

0.501

High

1055045

SCN5A
Sodium channel protein type 5 subunit alpha

1

20

High-throughput

0.501

High

1079738

SCN9A
Sodium channel protein type 9 subunit alpha

1

20

High-throughput

0.501

High

1265993

AP2B
Transcription factor AP-2-beta

1

1

High-throughput

0.501

High

151200

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

Small-scale

0.479

High

311447

SIX3
Homeobox protein SIX3

1

1

Small-scale

0.479

High

388735

HSPB1
Heat shock protein beta-1

1

4

Small-scale

0.479

High

397513

ADT2
ADP/ATP translocase 2

1

7

Small-scale

0.479

High

446341

PKHD1
Fibrocystin

1

4

Small-scale

0.479

High

518491

ADT3
ADP/ATP translocase 3

1

7

Small-scale

0.479

High

521307

SKI
Ski oncogene

1

4

Small-scale

0.479

High

521395

SKIL
Ski-like protein

1

4

Small-scale

0.479

High

555651

H2AX
Histone H2AX

1

8

Small-scale

0.479

High

591415

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

9

Small-scale

0.479

High

611504

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

10

Small-scale

0.479

High

846873

SMCA2
Probable global transcription activator SNF2L2

1

3

Small-scale

0.479

High

855737

KIF11
Kinesin-like protein KIF11

1

6

Small-scale

0.479

High

915510

ACTA
Actin, aortic smooth muscle

1

5

Small-scale

0.479

High

931419

YBOX1
Y-box-binding protein 1

1

6

Small-scale

0.479

High

957938

EFNB1
Ephrin-B1

1

1

Small-scale

0.479

High

1019647

ILF2
Interleukin enhancer-binding factor 2

1

4

Small-scale

0.479

High

1020936

TRAF2
TNF receptor-associated factor 2

1

16

Small-scale

0.479

High

1044440

PTC1
Protein patched homolog 1

1

13

Small-scale

0.479

High

1045144

RUNX3
Runt-related transcription factor 3

1

11

Small-scale

0.479

High

1054795

CASL
Enhancer of filamentation 1

1

5

Small-scale

0.479

High

1085687

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

Small-scale

0.479

High

1171774

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1237884

ENAH
Protein enabled homolog

1

20

Small-scale

0.479

High

1243030

GLIS3
Zinc finger protein GLIS3

1

4

Small-scale

0.479

High

1259479

SETD7
Histone-lysine N-methyltransferase SETD7

1

5

Small-scale

0.479

High

1299376

RBM14
RNA-binding protein 14

1

8

Small-scale

0.479

High

1311569

CCM2
Cerebral cavernous malformations 2 protein

1

1

Small-scale

0.479

High

1328810

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

11

Small-scale

0.479

High

1334871

MLXPL
Carbohydrate-responsive element-binding protein

1

8

Small-scale

0.479

High

1334873

PAR6A
Partitioning defective 6 homolog alpha

1

11

Small-scale

0.479

High

1334876

FMN2
Formin-2

1

4

Small-scale

0.479

High

1334878

UBP35
Ubiquitin carboxyl-terminal hydrolase 35

1

16

Small-scale

0.479

High

1334888

PIAS3
E3 SUMO-protein ligase PIAS3

1

3

Small-scale

0.479

High

654794

CALX
Calnexin

1

4

High-throughput

0.464

High

817029

TFPI2
Tissue factor pathway inhibitor 2

1

4

High-throughput

0.464

High

957483

IDD
Integral membrane protein DGCR2/IDD

1

10

High-throughput

0.464

High

1217223

TM139
Transmembrane protein 139

1

1

High-throughput

0.464

High

1330260

GCP60
Golgi resident protein GCP60

1

1

High-throughput

0.464

High

967002

SATB1
DNA-binding protein SATB1

1

0

Small-scale

0.458

High

1070095

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

0

Small-scale

0.458

High

1215849

INLR1
Interferon lambda receptor 1

1

0

Small-scale

0.458

High

1331846

ESF1
ESF1 homolog

1

0

Small-scale

0.458

High

415503

ATPB
ATP synthase subunit beta, mitochondrial

1

7

High-throughput

0.457

High

569126

DESM
Desmin

1

3

High-throughput

0.457

High

584305

TNNI3
Troponin I, cardiac muscle

1

1

High-throughput

0.457

High

596243

NEBU
Nebulin

1

9

High-throughput

0.457

High

644171

EF1G
Elongation factor 1-gamma

1

6

High-throughput

0.457

High

822811

TNNI2
Troponin I, fast skeletal muscle

1

1

High-throughput

0.457

High

827101

RM19
Large ribosomal subunit protein bL19m

1

2

High-throughput

0.457

High

888442

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

3

High-throughput

0.457

High

933057

ACTS
Actin, alpha skeletal muscle

1

3

High-throughput

0.457

High

1036914

SQSTM
Sequestosome-1

1

5

High-throughput

0.457

High

1050798

FHL2
Four and a half LIM domains protein 2

1

10

High-throughput

0.457

High

1052944

FLNC
Filamin-C

1

12

High-throughput

0.457

High

1060205

MYPC3
Myosin-binding protein C, cardiac-type

1

3

High-throughput

0.457

High

1123669

DCAF6
DDB1- and CUL4-associated factor 6

1

8

High-throughput

0.457

High

1133954

RM02
Large ribosomal subunit protein uL2m

1

3

High-throughput

0.457

High

1220157

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

3

High-throughput

0.457

High

1264807

TITIN
Titin

1

3

High-throughput

0.457

High

1334879

UXT
Protein UXT

1

1

High-throughput

0.457

High

174314

TELT
Telethonin

1

0

High-throughput

0.438

High

533631

TNNT1
Troponin T, slow skeletal muscle

1

0

High-throughput

0.438

High

1334872

MYOZ1
Myozenin-1

1

0

High-throughput

0.438

High

1334887

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

0

High-throughput

0.438

High

946974

RT22
Small ribosomal subunit protein mS22

1

1

Small-scale

0.437

High

1220473

DJC10
DnaJ homolog subfamily C member 10

1

8

Small-scale

0.437

High

1287622

KCD12
BTB/POZ domain-containing protein KCTD12

1

4

Small-scale

0.437

High

1334882

RT07
Small ribosomal subunit protein uS7m

1

4

Small-scale

0.437

High

1334884

RT23
Small ribosomal subunit protein mS23

1

1

Small-scale

0.437

High

282371

NEBL
Nebulette

1

14

High-throughput

0.417

High

671526

ECHM
Enoyl-CoA hydratase, mitochondrial

1

6

High-throughput

0.417

High

886341

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

1301149

EFGM
Elongation factor G, mitochondrial

1

9

High-throughput

0.417

High

325894

LATS1
Serine/threonine-protein kinase LATS1

1

15

Small-scale

0.408

High

1109812

C144B
Putative coiled-coil domain-containing protein 144B

1

4

High-throughput

0.407

High

1185471

LIGO2
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2

2

0

High-throughput

0.328

High

1128486

EFHC1
EF-hand domain-containing protein 1

1

0

High-throughput

0.261

Low

1246653

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.261

Low

1268794

RT31
Small ribosomal subunit protein mS31

1

0

Small-scale

0.249

Low

173199

NDUA1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

1

0

High-throughput

0.238

Low

1069061

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.238

Low

1221149

RM41
Large ribosomal subunit protein mL41

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024