HitPredict

Interactor 1: ACTZ (P61163)
Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)
Gene: ACTR1A

Interactor 2: DCTN4 (Q9UJW0)
Dynactin subunit 4 (Dyn4) (Dynactin subunit p62)
Gene: DCTN4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.890

Property	Details
Experiments	34079125, 33961781, 28718761, 10671518
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Actin~Dynactin_p62
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0005869 - dynactin complex GO:0005938 - cell cortex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 376 Hs			1 460
+	Hs
		785580 ACTY_HUMAN (1-376): 0: 728: 90.43		DCTN4_HUMAN (1-460): 0: 767: 100.00
+	Hs
		892100 ACTB_HUMAN (7-376): 0: 580: 52.41		DCTN4_HUMAN (1-460): 0: 767: 100.00
+	Hs
		930046 ACTG_HUMAN (7-376): 0: 580: 52.67		DCTN4_HUMAN (1-460): 0: 767: 100.00
+	Hs
		932440 ACTC_HUMAN (5-376): 0: 576: 52.93		DCTN4_HUMAN (1-460): 0: 767: 100.00
+	Dm
		800134 ACTZ_DROME (1-376): 0: 649: 79.26		Q7K130_DROME (3-427): 0: 532: 36.02