HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	31101761
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1, SH2~SOCS_box
Common GO terms	GO:0001817 - regulation of cytokine production GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 512
+	Hs
		439906 LCK_HUMAN (4-194): 1.14e-38: 141: 13.46		LYN_HUMAN (1-512): 0: 621: 100.00
+	Hs
		193194 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		SRC_HUMAN (1-510): 0: 591: 51.97
+	Hs
		193175 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		LCK_HUMAN (1-512): 0: 585: 63.62
+	Hs
		193176 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		FYN_HUMAN (1-510): 0: 583: 54.31
+	Hs
		193181 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		YES_HUMAN (1-510): 0: 581: 54.26
+	Hs
		439912 LCK_HUMAN (4-194): 1.14e-38: 141: 13.46		HCK_HUMAN (1-512): 0: 601: 70.70
+	Hs
		439926 LCK_HUMAN (4-194): 1.14e-38: 141: 13.46		SRC_HUMAN (1-510): 0: 591: 51.97
+	Hs
		155063 SOCS2_HUMAN (37-211): 1.63e-42: 143: 29.08		LCK_HUMAN (1-512): 0: 585: 63.62
+	Hs
		440226 CISH_HUMAN (22-211): 1.61e-41: 142: 26.45		LCK_HUMAN (1-512): 0: 585: 63.62
+	Hs
		440455 VAV2_HUMAN (1-175): 6.1e-39: 144: 17.68		FYN_HUMAN (1-510): 0: 583: 54.31
+	Hs
		439897 LCK_HUMAN (4-194): 1.14e-38: 141: 13.46		LCK_HUMAN (1-512): 0: 585: 63.62
+	Hs
		155065 SOCS2_HUMAN (37-211): 1.63e-42: 143: 29.08		YES_HUMAN (1-510): 0: 581: 54.26
+	Hs
		439898 LCK_HUMAN (4-194): 1.14e-38: 141: 13.46		FYN_HUMAN (1-510): 0: 583: 54.31
+	Hs
		439905 LCK_HUMAN (4-194): 1.14e-38: 141: 13.46		YES_HUMAN (1-510): 0: 581: 54.26
+	Hs
		193235 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		BLK_HUMAN (1-512): 0: 551: 59.77
+	Hs
		193164 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		ABL1_HUMAN (32-509): 1.52e-174: 523: 37.88
+	Dm
		362506 Q8INY1_DROME (26-210): 4.81e-43: 155: 23.00		SRC64_DROME (20-510): 2.44e-180: 519: 44.31
+	Dm
		362519 Q9VJA1_DROME (26-210): 2.57e-43: 155: 23.00		SRC64_DROME (20-510): 2.44e-180: 519: 44.31
+	Hs
		193263 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		ITK_HUMAN (35-503): 2.9e-164: 480: 35.83
+	Hs
		193227 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		TEC_HUMAN (35-505): 1.07e-162: 477: 35.27