HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	31101761
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1, SH2~SOCS_box
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035556 - intracellular signal transduction GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 536
+	Hs
		439926 LCK_HUMAN (4-194): 1.14e-38: 141: 13.46		SRC_HUMAN (1-536): 0: 644: 100.00
+	Hs
		193181 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		YES_HUMAN (1-536): 0: 594: 73.85
+	Hs
		193176 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		FYN_HUMAN (1-536): 0: 586: 68.39
+	Hs
		155065 SOCS2_HUMAN (37-211): 1.63e-42: 143: 29.08		YES_HUMAN (1-536): 0: 594: 73.85
+	Hs
		439905 LCK_HUMAN (4-194): 1.14e-38: 141: 13.46		YES_HUMAN (1-536): 0: 594: 73.85
+	Hs
		440455 VAV2_HUMAN (1-175): 6.1e-39: 144: 17.68		FYN_HUMAN (1-536): 0: 586: 68.39
+	Hs
		439898 LCK_HUMAN (4-194): 1.14e-38: 141: 13.46		FYN_HUMAN (1-536): 0: 586: 68.39
+	Hs
		193175 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		LCK_HUMAN (75-534): 0: 544: 58.48
+	Hs
		439912 LCK_HUMAN (4-194): 1.14e-38: 141: 13.46		HCK_HUMAN (1-531): 0: 560: 55.18
+	Hs
		193182 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		LYN_HUMAN (1-531): 0: 522: 52.82
+	Hs
		155063 SOCS2_HUMAN (37-211): 1.63e-42: 143: 29.08		LCK_HUMAN (75-534): 0: 544: 58.48
+	Hs
		440226 CISH_HUMAN (22-211): 1.61e-41: 142: 26.45		LCK_HUMAN (75-534): 0: 544: 58.48
+	Hs
		439897 LCK_HUMAN (4-194): 1.14e-38: 141: 13.46		LCK_HUMAN (75-534): 0: 544: 58.48
+	Hs
		193235 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		BLK_HUMAN (1-534): 3.52e-178: 512: 54.21
+	Hs
		193164 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		ABL1_HUMAN (47-536): 4.29e-165: 499: 40.20
+	Hs
		439906 LCK_HUMAN (4-194): 1.14e-38: 141: 13.46		LYN_HUMAN (1-531): 0: 522: 52.82
+	Dm
		362506 Q8INY1_DROME (26-210): 4.81e-43: 155: 23.00		SRC64_DROME (42-535): 4.81e-175: 506: 49.70
+	Dm
		362519 Q9VJA1_DROME (26-210): 2.57e-43: 155: 23.00		SRC64_DROME (42-535): 4.81e-175: 506: 49.70
+	Hs
		193263 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		ITK_HUMAN (54-525): 6.43e-159: 468: 34.23
+	Hs
		193227 SOCS1_HUMAN (1-211): 2.12e-51: 166: 100.00		TEC_HUMAN (83-528): 1.55e-152: 452: 37.36