HitPredict

Interactor 1: HDAC2 (P70288)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) (YY1 transcription factor-binding protein)
Gene: HDAC2

Interactor 2: RCOR2 (Q8C796)
REST corepressor 2 (M-CoREST)
Gene: RCOR2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	19424149
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl, Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0005634 - nucleus GO:0019899 - enzyme binding GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Mm			1 523
+	Hs
		1315917 HDAC2_HUMAN (1-488): 0: 707: 99.39		RCOR2_HUMAN (1-523): 2.26e-146: 432: 97.51
+	Hs
		1368168 HDAC2_HUMAN (1-488): 0: 707: 99.39		RCOR3_HUMAN (46-520): 1.38e-129: 388: 57.81
+	Hs
		1368196 HDAC2_HUMAN (1-488): 0: 707: 99.39		RCOR1_HUMAN (15-425): 4.75e-113: 345: 52.04
+	Mm
		1000030 HDAC2_MOUSE (1-488): 0: 706: 100.00		RCOR1_MOUSE (15-428): 9.04e-111: 339: 51.65
+	Hs
		1368092 HDAC2_HUMAN (1-488): 0: 707: 99.39		MTA3_HUMAN (24-470): 3.07e-105: 328: 15.57
+	Hs
		316935 HDAC2_HUMAN (1-488): 0: 707: 99.39		MTA2_HUMAN (5-514): 2.78e-93: 300: 18.01
+	Mm
		1000040 HDAC2_MOUSE (1-488): 0: 706: 100.00		MTA2_MOUSE (5-514): 1.83e-92: 297: 17.31
+	Hs
		1102617 HDAC2_HUMAN (1-488): 0: 707: 99.39		MTA1_HUMAN (24-471): 1.17e-89: 291: 15.31
+	Mm
		1000031 HDAC2_MOUSE (1-488): 0: 706: 100.00		MTA1_MOUSE (24-471): 2.05e-86: 283: 15.10
+	Mm
		148723 HDAC1_MOUSE (1-446): 0: 647: 89.46		RCOR1_MOUSE (15-428): 9.04e-111: 339: 51.65
+	Dm
		1374489 HDAC1_DROME (5-472): 0: 654: 77.71		Q9VNF6_DROME (23-516): 7.71e-85: 282: 13.42
+	Dm
		84936 HDAC1_DROME (5-472): 0: 654: 77.71		B7Z0T5_DROME (23-516): 6.79e-85: 281: 13.42
+	Mm
		148724 HDAC1_MOUSE (1-446): 0: 647: 89.46		MTA1_MOUSE (24-471): 2.05e-86: 283: 15.10
+	Hs
		1322540 HDAC2_HUMAN (1-488): 0: 707: 99.39		MIER1_HUMAN (2-331): 3.09e-61: 211: 17.61
+	Hs
		1368170 HDAC2_HUMAN (1-488): 0: 707: 99.39		RERE_HUMAN (8-522): 2.49e-56: 205: 16.17
+	Hs
		1368228 HDAC2_HUMAN (1-488): 0: 707: 99.39		NCOR2_HUMAN (81-512): 5.71e-56: 204: 16.90
+	Hs
		1277269 HDAC2_HUMAN (1-488): 0: 707: 99.39		MIER3_HUMAN (5-233): 1.72e-56: 199: 21.15
+	Hs
		1324704 HDAC2_HUMAN (1-488): 0: 707: 99.39		MIER2_HUMAN (5-328): 1.23e-55: 197: 17.90
+	Dm
		1202433 HDAC1_DROME (5-472): 0: 654: 77.71		RCOR_DROME (7-512): 1.47e-53: 192: 25.23
+	Mm
		148713 HDAC1_MOUSE (1-446): 0: 647: 89.46		RERE_MOUSE (8-520): 1.52e-53: 197: 14.89