HitPredict

Interactor 1: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Interactor 2: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 606 Hs			1 803
+	Hs
		201182 M3K7_HUMAN (1-606): 0: 574: 100.00		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		201181 M3K7_HUMAN (1-606): 0: 574: 100.00		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Mm
		432432 M3K7_MOUSE (1-606): 0: 545: 94.88		HS90A_MOUSE (60-783): 0: 985: 45.28
+	Hs
		438096 FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431765 FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		438167 FAK2_HUMAN (31-603): 1.5e-116: 372: 18.58		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431848 FAK2_HUMAN (31-603): 1.5e-116: 372: 18.58		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		437918 EPHA2_HUMAN (16-358): 2.84e-101: 331: 26.67		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431561 EPHA2_HUMAN (16-358): 2.84e-101: 331: 26.67		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		438651 RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		432396 RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Zm
		8229 A0A1D6ELX5_MAIZE (31-292): 3.24e-102: 328: 33.21		A0A1D6LMW9_MAIZE (14-781): 0: 889: 46.68
+	Hs
		438088 M3K10_HUMAN (29-282): 2.43e-45: 174: 38.89		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431754 M3K10_HUMAN (29-282): 2.43e-45: 174: 38.89		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		438242 TNI3K_HUMAN (35-281): 1.8e-39: 156: 37.55		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		438073 M3K9_HUMAN (3-285): 4.42e-39: 155: 36.55		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431933 TNI3K_HUMAN (35-281): 1.8e-39: 156: 37.55		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		438211 M3K11_HUMAN (29-287): 5.32e-37: 149: 35.27		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431735 M3K9_HUMAN (3-285): 4.42e-39: 155: 36.55		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		431899 M3K11_HUMAN (29-287): 5.32e-37: 149: 35.27		HS90A_HUMAN (60-783): 0: 990: 45.34