HitPredict

Interactor 1: PJA2 (O43164)
E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2)
Gene: PJA2

Interactor 2: UBE2W (Q96B02)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Gene: UBE2W

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 708 Hs			1 151
+	Hs
		208592 PJA2_HUMAN (1-708): 0: 581: 100.00		UB2D4_HUMAN (4-150): 2.13e-69: 207: 35.37
+	Hs
		208482 PJA2_HUMAN (1-708): 0: 581: 100.00		UB2D1_HUMAN (4-150): 5.71e-69: 206: 34.69
+	Hs
		208495 PJA2_HUMAN (1-708): 0: 581: 100.00		UB2D2_HUMAN (4-150): 3.15e-68: 204: 33.33
+	Hs
		208490 PJA2_HUMAN (1-708): 0: 581: 100.00		UB2D3_HUMAN (4-150): 9.51e-67: 201: 33.33
+	Hs
		982252 PJA1_HUMAN (12-681): 1.15e-128: 397: 42.92		UB2D2_HUMAN (4-150): 3.15e-68: 204: 33.33
+	Hs
		957139 PJA1_HUMAN (12-681): 1.15e-128: 397: 42.92		UB2D3_HUMAN (4-150): 9.51e-67: 201: 33.33
+	Hs
		1339826 PJA1_HUMAN (12-681): 1.15e-128: 397: 42.92		UB2E3_HUMAN (1-150): 5.7e-65: 198: 35.33
+	At
		101147 F4IQ07_ARATH (145-687): 3.76e-61: 217: 14.34		UBC9_ARATH (4-150): 8e-68: 203: 32.65
+	At
		101152 F4IQ07_ARATH (145-687): 3.76e-61: 217: 14.34		UBC29_ARATH (4-150): 9.28e-66: 198: 30.61
+	At
		762768 Q8VYL4_ARATH (145-687): 1.61e-56: 203: 14.34		UBC9_ARATH (4-150): 8e-68: 203: 32.65
+	At
		1354500 Q8VYL4_ARATH (145-687): 1.61e-56: 203: 14.34		UBC29_ARATH (4-150): 9.28e-66: 198: 30.61
+	At
		101149 F4IQ07_ARATH (145-687): 3.76e-61: 217: 14.34		UBC18_ARATH (4-149): 2.13e-59: 183: 50.00
+	At
		101150 F4IQ07_ARATH (145-687): 3.76e-61: 217: 14.34		UBC16_ARATH (7-149): 1.88e-59: 183: 51.72
+	Hs
		906796 RNF12_HUMAN (124-679): 2.11e-50: 188: 15.36		UB2D1_HUMAN (4-150): 5.71e-69: 206: 34.69
+	Hs
		982337 RNF12_HUMAN (124-679): 2.11e-50: 188: 15.36		UB2D2_HUMAN (4-150): 3.15e-68: 204: 33.33
+	Hs
		957214 RNF12_HUMAN (124-679): 2.11e-50: 188: 15.36		UB2D3_HUMAN (4-150): 9.51e-67: 201: 33.33
+	Hs
		1397296 RNF12_HUMAN (124-679): 2.11e-50: 188: 15.36		UB2E2_HUMAN (1-150): 1.08e-65: 200: 34.67
+	At
		1354497 Q8VYL4_ARATH (145-687): 1.61e-56: 203: 14.34		UBC18_ARATH (4-149): 2.13e-59: 183: 50.00
+	At
		1354498 Q8VYL4_ARATH (145-687): 1.61e-56: 203: 14.34		UBC16_ARATH (7-149): 1.88e-59: 183: 51.72
+	Hs
		909397 RNF12_HUMAN (124-679): 2.11e-50: 188: 15.36		UB2E1_HUMAN (1-150): 1.19e-63: 195: 34.00