HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 1746
+	Hs
		782826 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		411858 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		924867 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Mm
		1141136 GRB2_MOUSE (1-61): 1.04e-18: 85.9: 27.42		PEAK1_MOUSE (1-1746): 0: 2159: 85.76
+	Hs
		681710 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Mm
		554895 P70304_MOUSE (166-379): 5.35e-24: 105: 16.36		KPCE_MOUSE (1352-1719): 4.36e-92: 318: 13.12
+	Hs
		655233 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Mm
		403411 SRC_MOUSE (6-153): 5.44e-20: 93.3: 17.33		KPCE_MOUSE (1352-1719): 4.36e-92: 318: 13.12
+	Hs
		412046 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Mm
		411915 LCK_MOUSE (3-188): 2.6e-19: 91.4: 16.58		KPCE_MOUSE (1352-1719): 4.36e-92: 318: 13.12
+	Hs
		568554 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		411994 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		129195 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		846470 BLK_HUMAN (7-204): 3.35e-19: 91: 19.80		KCC1A_HUMAN (1453-1709): 3.73e-56: 202: 16.48
+	Hs
		616675 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		KS6B1_HUMAN (1453-1683): 8.42e-45: 173: 16.17
+	Hs
		883142 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		HUNK_HUMAN (1405-1659): 1.25e-44: 176: 20.61
+	Hs
		522780 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		KS6B1_HUMAN (1453-1683): 8.42e-45: 173: 16.17
+	Hs
		782802 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		PRAG1_HUMAN (1-91): 6.17e-28: 125: 40.43
+	Hs
		924654 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		PEAK3_HUMAN (1653-1743): 1.22e-30: 129: 38.46
+	Hs
		924680 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		PRAG1_HUMAN (1-91): 6.17e-28: 125: 40.43