HitPredict

Interactor 1: PSA1 (O44156)
Proteasome subunit alpha type-1 (Proteasome subunit alpha 6)
Gene: pas-6

Interactor 2: PSA2 (Q27488)
Proteasome subunit alpha type-2 (Proteasome subunit alpha 2)
Gene: pas-2

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.918

Property	Details
Experiments	12679813, 14704431, 11559592, 18692475, unassigned701
Identification Methods	two hybrid, two hybrid pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N, Proteasome_A_N~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0019773 - proteasome core complex, alpha-subunit complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 260 Ce			1 231
+	Hs
		637663 PSA2_HUMAN (1-237): 3.44e-109: 316: 28.03		PSA6_HUMAN (2-231): 5.65e-102: 297: 32.77
+	Dm
		771318 Q9VK14_DROME (1-260): 1.05e-100: 297: 44.62		PSA2_DROME (2-231): 4.04e-109: 314: 60.52
+	Hs
		637376 PSA1_HUMAN (1-259): 4.08e-107: 312: 53.44		PSA6_HUMAN (2-231): 5.65e-102: 297: 32.77
+	Dm
		522481 PSA1_DROME (1-238): 2e-98: 290: 48.96		PSA2_DROME (2-231): 4.04e-109: 314: 60.52
+	Hs
		637624 PSA2_HUMAN (1-237): 3.44e-109: 316: 28.03		PSA2_HUMAN (3-231): 3.76e-90: 266: 63.79
+	Hs
		637631 PSA2_HUMAN (1-237): 3.44e-109: 316: 28.03		PSA5_HUMAN (3-231): 3.82e-90: 266: 28.57
+	Dm
		771303 PSA2_DROME (1-236): 2.18e-106: 309: 28.57		PSA5_DROME (3-231): 4.28e-92: 272: 31.67
+	Ss
		94582 F2Z5L7_PIG (1-259): 4.08e-107: 312: 53.44		F1SBA5_PIG (1-225): 7.95e-91: 269: 32.47
+	Hs
		156224 PSA2_HUMAN (1-237): 3.44e-109: 316: 28.03		PSA7_HUMAN (5-229): 1.95e-88: 263: 32.90
+	Hs
		637316 PSA1_HUMAN (1-259): 4.08e-107: 312: 53.44		PSA2_HUMAN (3-231): 3.76e-90: 266: 63.79
+	Hs
		637325 PSA1_HUMAN (1-259): 4.08e-107: 312: 53.44		PSA5_HUMAN (3-231): 3.82e-90: 266: 28.57
+	Hs
		637626 PSA2_HUMAN (1-237): 3.44e-109: 316: 28.03		PSA4_HUMAN (1-228): 3.53e-88: 262: 34.03
+	Ss
		94704 F2Z5L7_PIG (1-259): 4.08e-107: 312: 53.44		F2Z5K2_PIG (3-231): 3.82e-90: 266: 28.57
+	Hs
		156223 PSA1_HUMAN (1-259): 4.08e-107: 312: 53.44		PSA7_HUMAN (5-229): 1.95e-88: 263: 32.90
+	Hs
		637318 PSA1_HUMAN (1-259): 4.08e-107: 312: 53.44		PSA4_HUMAN (1-228): 3.53e-88: 262: 34.03
+	Dm
		522499 PSA1_DROME (1-238): 2e-98: 290: 48.96		PSA5_DROME (3-231): 4.28e-92: 272: 31.67
+	Hs
		156230 PSA7_HUMAN (6-234): 2.19e-96: 284: 30.17		PSA5_HUMAN (3-231): 3.82e-90: 266: 28.57
+	Hs
		156169 PSA7_HUMAN (6-234): 2.19e-96: 284: 30.17		PSA7_HUMAN (5-229): 1.95e-88: 263: 32.90
+	Hs
		156226 PSA7_HUMAN (6-234): 2.19e-96: 284: 30.17		PSA4_HUMAN (1-228): 3.53e-88: 262: 34.03