Protein: SNX3
Sorting nexin-3 (Protein SDP3)

Gene: SNX3
Organism: Homo sapiens
Interactions: 163
UniProt ID: O60493

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005769 - early endosome
GO:0005829 - cytosol
GO:0009617 - response to bacterium
GO:0010008 - endosome membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

249681

SNX12
Sorting nexin-12

3

19

High-throughput

0.839

High

249537

SNX3
Sorting nexin-3

2

18

High-throughput

0.754

High

249652

VPS35
Vacuolar protein sorting-associated protein 35

5

8

Small-scale

0.721

High

249589

RAB7A
Ras-related protein Rab-7a

3

20

Small-scale

0.660

High

249551

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

1

High-throughput

0.628

High

249582

EAA3
Excitatory amino acid transporter 3

2

1

High-throughput

0.628

High

162996

H17B6
17-beta-hydroxysteroid dehydrogenase type 6

2

1

High-throughput

0.611

High

249628

SETD3
Actin-histidine N-methyltransferase

2

2

High-throughput

0.611

High

249553

CP1A1
Cytochrome P450 1A1

3

1

High-throughput

0.609

High

249670

RPRM
Protein reprimo

2

2

High-throughput

0.606

High

249539

VP26A
Vacuolar protein sorting-associated protein 26A

2

5

High-throughput

0.601

High

249616

VP26B
Vacuolar protein sorting-associated protein 26B

2

5

High-throughput

0.601

High

249678

VPS29
Vacuolar protein sorting-associated protein 29

2

4

High-throughput

0.601

High

221068

SPY2
Protein sprouty homolog 2

2

0

High-throughput

0.585

High

249675

MBD5
Methyl-CpG-binding domain protein 5

2

0

High-throughput

0.585

High

249548

RASH
GTPase HRas

2

15

High-throughput

0.584

High

249549

RASK
GTPase KRas

2

18

High-throughput

0.584

High

249558

LAMP1
Lysosome-associated membrane glycoprotein 1

2

15

High-throughput

0.584

High

249567

RAB4A
Ras-related protein Rab-4A

2

12

High-throughput

0.584

High

249590

RAB9A
Ras-related protein Rab-9A

2

19

High-throughput

0.584

High

249682

GAB2
GRB2-associated-binding protein 2

1

5

High-throughput

0.575

High

249594

CAV3
Caveolin-3

2

1

High-throughput

0.574

High

249640

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

1

High-throughput

0.574

High

249615

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

7

High-throughput

0.573

High

249566

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.571

High

249618

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

4

High-throughput

0.571

High

249686

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

2

4

High-throughput

0.558

High

249579

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.552

High

158383

RFXK
DNA-binding protein RFXANK

1

3

High-throughput

0.536

High

180184

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.536

High

249541

MPDZ
Multiple PDZ domain protein

1

1

High-throughput

0.536

High

249565

PYRG1
CTP synthase 1

1

1

High-throughput

0.536

High

249580

IF4A3
Eukaryotic initiation factor 4A-III

1

1

High-throughput

0.536

High

249586

ARL4D
ADP-ribosylation factor-like protein 4D

1

20

High-throughput

0.536

High

249593

FCGRN
IgG receptor FcRn large subunit p51

1

2

High-throughput

0.536

High

249636

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.536

High

249637

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

2

High-throughput

0.536

High

249642

TFG
Protein TFG

1

2

High-throughput

0.536

High

249643

RN166
E3 ubiquitin-protein ligase RNF166

1

2

High-throughput

0.536

High

249645

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.536

High

249650

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

2

High-throughput

0.536

High

249651

FACC1
Flagellum-associated coiled-coil domain-containing protein 1

1

1

High-throughput

0.536

High

249660

DERL2
Derlin-2

1

2

High-throughput

0.536

High

249669

PYRG2
CTP synthase 2

1

1

High-throughput

0.536

High

249569

XPA
DNA repair protein complementing XP-A cells

1

0

High-throughput

0.513

High

249572

ITPI2
Protein ITPRID2

1

0

High-throughput

0.513

High

249577

SPB5
Serpin B5

1

0

High-throughput

0.513

High

249591

STA5B
Signal transducer and activator of transcription 5B

1

0

High-throughput

0.513

High

249595

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

249610

KCAB2
Voltage-gated potassium channel subunit beta-2

1

0

High-throughput

0.513

High

249612

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.513

High

249617

UROL1
Uromodulin-like 1

1

0

High-throughput

0.513

High

249630

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

0

High-throughput

0.513

High

249638

DDX55
ATP-dependent RNA helicase DDX55

1

0

High-throughput

0.513

High

249639

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

0

High-throughput

0.513

High

249646

PTER
N-acetyltaurine hydrolase

1

0

High-throughput

0.513

High

249659

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

249666

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

249671

CENPM
Centromere protein M

1

0

High-throughput

0.513

High

249687

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

249613

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

3

Small-scale

0.501

High

249662

GO45
Golgin-45

1

0

High-throughput

0.493

High

249573

CXB2
Gap junction beta-2 protein

1

2

High-throughput

0.489

High

249632

CLASR
CLK4-associating serine/arginine rich protein

1

1

High-throughput

0.489

High

249654

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.489

High

249664

KLK15
Kallikrein-15

1

4

High-throughput

0.489

High

249684

NTNG1
Netrin-G1

1

6

High-throughput

0.489

High

249685

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.489

High

249653

BARD1
BRCA1-associated RING domain protein 1

1

4

High-throughput

0.481

High

169840

AURKA
Aurora kinase A

1

6

High-throughput

0.479

High

179764

BET1
BET1 homolog

1

4

High-throughput

0.479

High

189332

STX7
Syntaxin-7

1

7

High-throughput

0.479

High

240223

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.479

High

249542

RHBT1
Rho-related BTB domain-containing protein 1

1

13

High-throughput

0.479

High

249546

ABL1
Tyrosine-protein kinase ABL1

1

9

High-throughput

0.479

High

249547

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

249550

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

249552

TFR1
Transferrin receptor protein 1

1

3

High-throughput

0.479

High

249554

FYN
Tyrosine-protein kinase Fyn

1

9

High-throughput

0.479

High

249555

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.479

High

249557

EPB41
Protein 4.1

1

2

High-throughput

0.479

High

249559

SRC
Proto-oncogene tyrosine-protein kinase Src

1

9

High-throughput

0.479

High

249560

IFM1
Interferon-induced transmembrane protein 1

1

6

High-throughput

0.479

High

249561

LAMP2
Lysosome-associated membrane glycoprotein 2

1

15

High-throughput

0.479

High

249563

NCK1
SH2/SH3 adapter protein NCK1

1

17

High-throughput

0.479

High

249564

RHOQ
Rho-related GTP-binding protein RhoQ

1

8

High-throughput

0.479

High

249568

RAB5A
Ras-related protein Rab-5A

1

15

High-throughput

0.479

High

249570

CRCM
Colorectal mutant cancer protein

1

3

High-throughput

0.479

High

249571

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

249574

MARCS
Myristoylated alanine-rich C-kinase substrate

1

5

High-throughput

0.479

High

249576

BASI
Basigin

1

2

High-throughput

0.479

High

249584

CRK
Adapter molecule crk

1

16

High-throughput

0.479

High

249588

RAB5C
Ras-related protein Rab-5C

1

15

High-throughput

0.479

High

249592

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

249596

RAB25
Ras-related protein Rab-25

1

10

High-throughput

0.479

High

249598

RAB2A
Ras-related protein Rab-2A

1

12

High-throughput

0.479

High

249599

ARF3
ADP-ribosylation factor 3

1

6

High-throughput

0.479

High

249600

1433G
14-3-3 protein gamma

1

8

High-throughput

0.479

High

249601

ARF6
ADP-ribosylation factor 6

1

6

High-throughput

0.479

High

249602

RB11A
Ras-related protein Rab-11A

1

9

High-throughput

0.479

High

249603

GRB2
Growth factor receptor-bound protein 2

1

19

High-throughput

0.479

High

249606

IFM3
Interferon-induced transmembrane protein 3

1

6

High-throughput

0.479

High

249607

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

249609

FOXC1
Forkhead box protein C1

1

3

High-throughput

0.479

High

249611

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

4

High-throughput

0.479

High

249620

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.479

High

249621

LTOR1
Ragulator complex protein LAMTOR1

1

8

High-throughput

0.479

High

249622

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

249624

RHOU
Rho-related GTP-binding protein RhoU

1

14

High-throughput

0.479

High

249627

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.479

High

249633

ARL14
ADP-ribosylation factor-like protein 14

1

8

High-throughput

0.479

High

249634

FHI1B
FHF complex subunit HOOK-interacting protein 1B

1

5

High-throughput

0.479

High

249647

OPTN
Optineurin

1

6

High-throughput

0.479

High

249657

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

249661

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

249665

RHOJ
Rho-related GTP-binding protein RhoJ

1

8

High-throughput

0.479

High

249674

ARL15
ADP-ribosylation factor-like protein 15

1

9

High-throughput

0.479

High

249676

ANFY1
Rabankyrin-5

1

6

High-throughput

0.479

High

249679

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

249683

LAMP3
Lysosome-associated membrane glycoprotein 3

1

15

High-throughput

0.479

High

249672

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

4

High-throughput

0.470

High

249562

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

249578

SCNNA
Epithelial sodium channel subunit alpha

1

0

Small-scale

0.458

High

249581

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

249614

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.458

High

249680

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

249619

MYOME
Myomegalin

1

1

Small-scale

0.457

High

142246

PEX7
Peroxisomal targeting signal 2 receptor

1

4

High-throughput

0.445

High

249556

PGFRB
Platelet-derived growth factor receptor beta

1

17

High-throughput

0.445

High

249575

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.445

High

249644

P33MX
Putative monooxygenase p33MONOX

1

1

High-throughput

0.445

High

249668

ITM2C
Integral membrane protein 2C

1

2

High-throughput

0.445

High

249673

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

249538

T22D2
TSC22 domain family protein 2

1

2

Small-scale

0.439

High

249623

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.439

High

217579

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.437

High

249583

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.437

High

249585

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

249608

FHI1A
FHF complex subunit HOOK-interacting protein 1A

1

5

High-throughput

0.437

High

249625

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.437

High

249626

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

249629

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

249677

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.437

High

249604

SSBP2
Single-stranded DNA-binding protein 2

1

0

High-throughput

0.426

High

249641

CTL1
Choline transporter-like protein 1

1

0

High-throughput

0.426

High

249655

MCRI2
MAPK regulated corepressor interacting protein 2

1

0

High-throughput

0.426

High

249540

STX11
Syntaxin-11

1

6

High-throughput

0.417

High

249543

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.407

High

249597

T2R41
Taste receptor type 2 member 41

3

0

High-throughput

0.347

High

249656

SCNM1
Sodium channel modifier 1

3

0

High-throughput

0.347

High

249667

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.328

High

249635

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

2

0

High-throughput

0.318

High

214106

DHH
Desert hedgehog protein

1

0

High-throughput

0.279

Low

249605

RT05
Small ribosomal subunit protein uS5m

1

0

High-throughput

0.279

Low

249631

T183A
Transmembrane protein 183A

1

0

High-throughput

0.279

Low

249648

MRAP2
Melanocortin-2 receptor accessory protein 2

1

0

High-throughput

0.279

Low

249658

ANO3
Anoctamin-3

1

0

High-throughput

0.279

Low

249663

PPIL3
Peptidyl-prolyl cis-trans isomerase-like 3

1

0

High-throughput

0.279

Low

249587

DNLI4
DNA ligase 4

1

0

High-throughput

0.251

Low

249544

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.232

Low

249545

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

249649

SYMM
Methionine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025