HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: VASP (P50552)
Vasodilator-stimulated phosphoprotein (VASP)
Gene: VASP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0030838 - positive regulation of actin filament polymerization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 380
+	Hs
		222144 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		MINK1_HUMAN (88-364): 7.53e-36: 141: 15.90
+	Hs
		594048 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		MINK1_HUMAN (88-364): 7.53e-36: 141: 15.90
+	Ce
		115878 Q95PW9_CAEEL (1-379): 2.06e-70: 227: 37.63		H2L0C7_CAEEL (14-252): 5.07e-46: 161: 20.15
+	Hs
		136408 P85B_HUMAN (21-380): 2.06e-23: 104: 12.80		SPRE1_HUMAN (2-343): 2.85e-90: 280: 15.66
+	Hs
		463615 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		SPRE1_HUMAN (2-343): 2.85e-90: 280: 15.66
+	Hs
		440609 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		SPRE1_HUMAN (2-343): 2.85e-90: 280: 15.66
+	Hs
		896505 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		VASP_HUMAN (1-380): 1.44e-91: 281: 100.00
+	Hs
		473481 HCK_HUMAN (2-184): 1.58e-23: 103: 21.74		EVL_HUMAN (1-375): 2.07e-60: 202: 43.68
+	Hs
		463826 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		EVL_HUMAN (1-375): 2.07e-60: 202: 43.68
+	Hs
		557511 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		EVL_HUMAN (1-375): 2.07e-60: 202: 43.68
+	Hs
		440790 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		DYN3_HUMAN (15-212): 2.78e-38: 148: 20.98
+	Hs
		463648 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		MINK1_HUMAN (88-364): 7.53e-36: 141: 15.90
+	Dm
		1061430 GRAP_DROME (204-368): 9.23e-17: 80.1: 30.72		ENA_DROME (2-235): 1.22e-41: 158: 36.33
+	Mm
		1221239 GRB2_MOUSE (1-60): 2.89e-18: 84.4: 27.87		DYN3_MOUSE (15-212): 1.15e-38: 149: 20.49
+	Hs
		440144 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		MINK1_HUMAN (88-364): 7.53e-36: 141: 15.90
+	Hs
		988036 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		DYN3_HUMAN (15-212): 2.78e-38: 148: 20.98
+	Hs
		987773 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		MINK1_HUMAN (88-364): 7.53e-36: 141: 15.90
+	Hs
		319045 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		K0754_HUMAN (95-330): 9.01e-21: 96.6: 17.72
+	Mm
		813513 FYN_MOUSE (7-140): 3.37e-22: 99.9: 19.85		ENAH_MOUSE (109-379): 3.13e-16: 82.4: 28.17
+	Mm
		431342 SRC_MOUSE (6-155): 4.82e-19: 90.6: 17.11		ENAH_MOUSE (109-379): 3.13e-16: 82.4: 28.17