HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: DYN3 (Q9UQ16)
Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin)
Gene: DNM3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.963

Property	Details
Experiments	28514442, 31980649, 33961781, 19380743, 21706016, unassigned2173, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0031623 - receptor internalization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 869
+	Mm
		1221239 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		DYN3_MOUSE (1-869): 0: 1071: 95.99
+	Hs
		896723 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Mm
		810547 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		DYN2_MOUSE (1-869): 0: 1037: 79.21
+	Mm
		810522 GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54		DYN1_MOUSE (1-847): 0: 1034: 78.90
+	Hs
		987565 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		DYN1_HUMAN (1-852): 0: 1035: 78.56
+	Rn
		638953 GRB2_RAT (1-217): 1.28e-70: 216: 100.00		DYN1_RAT (1-852): 0: 1027: 78.22
+	Hs
		896746 GRAP_HUMAN (1-213): 8.58e-61: 191: 56.74		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		362414 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		DYN3_HUMAN (1-869): 0: 1080: 100.00
+	Hs
		439999 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Dm
		693526 GRAP_DROME (1-215): 1.24e-56: 180: 62.33		DYN_DROME (6-861): 0: 974: 64.46
+	Hs
		440790 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		DYN3_HUMAN (1-869): 0: 1080: 100.00
+	Ce
		711448 SEM5_CAEEL (1-216): 5.16e-61: 192: 57.60		DYN1_CAEEL (3-815): 0: 946: 62.09
+	Hs
		362214 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		593970 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		DYN1_HUMAN (1-852): 0: 1035: 78.56
+	Hs
		362253 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		DYN1_HUMAN (1-852): 0: 1035: 78.56
+	Hs
		896780 SH319_HUMAN (8-215): 6.01e-18: 83.5: 17.14		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		896907 ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		440447 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		896763 ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Ce
		234032 SRC2_CAEEL (118-215): 6.76e-13: 68.9: 22.00		DYN1_CAEEL (3-815): 0: 946: 62.09