HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: SRPK1 (Q96SB4)
SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)
Gene: SRPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.550

Property	Details
Experiments	23602568
Identification Methods	enzymatic study, protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 655
+	Hs
		222051 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		SRPK2_HUMAN (48-655): 2.61e-129: 398: 54.43
+	Hs
		699759 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		KS6A2_HUMAN (67-653): 3.92e-125: 389: 13.68
+	Hs
		136390 P85B_HUMAN (21-380): 2.06e-23: 104: 12.80		KS6A2_HUMAN (67-653): 3.92e-125: 389: 13.68
+	Hs
		440568 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		KS6A2_HUMAN (67-653): 3.92e-125: 389: 13.68
+	Hs
		557220 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		SRPK2_HUMAN (48-655): 2.61e-129: 398: 54.43
+	Hs
		463100 YES_HUMAN (6-137): 1.81e-19: 91.7: 20.15		KS6A2_HUMAN (67-653): 3.92e-125: 389: 13.68
+	Hs
		593917 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		MARK3_HUMAN (409-655): 3.4e-48: 182: 12.65
+	Hs
		699657 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		KS6A3_HUMAN (1-353): 8.49e-77: 261: 14.85
+	Hs
		440452 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		KS6A3_HUMAN (1-353): 8.49e-77: 261: 14.85
+	Hs
		557185 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		KS6A3_HUMAN (1-353): 8.49e-77: 261: 14.85
+	Hs
		463339 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		CDK2_HUMAN (414-653): 7.85e-67: 222: 19.43
+	Hs
		463345 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		MARK3_HUMAN (409-655): 3.4e-48: 182: 12.65
+	Hs
		463607 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		MARK2_HUMAN (409-654): 1.28e-47: 181: 13.10
+	Hs
		439960 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		MARK3_HUMAN (409-655): 3.4e-48: 182: 12.65
+	Hs
		440132 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		MARK2_HUMAN (409-654): 1.28e-47: 181: 13.10
+	Dm
		1304202 Q8INU2_DROME (1-58): 1.14e-18: 90.1: 35.00		JIL1_DROME (2-380): 2.31e-40: 160: 9.93
+	Dm
		1169475 Q1WWC9_DROME (1-58): 1.42e-18: 89.8: 35.00		JIL1_DROME (2-380): 2.31e-40: 160: 9.93
+	Hs
		440570 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		KS6A1_HUMAN (447-655): 5.56e-25: 112: 15.46
+	Hs
		841011 FRK_HUMAN (3-171): 1.38e-17: 86: 15.39		KS6A1_HUMAN (447-655): 5.56e-25: 112: 15.46
+	Hs
		463709 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		MARK4_HUMAN (456-654): 2.57e-18: 91.4: 18.05