HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.550

Property	Details
Experiments	23602568
Identification Methods	enzymatic study, protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 688
+	Hs
		222183 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		SRPK1_HUMAN (27-688): 2.64e-125: 388: 53.00
+	Hs
		557220 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00
+	Hs
		913639 VAV2_HUMAN (3-254): 1.88e-09: 61.3: 11.77		SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00
+	Hs
		463339 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		CDK2_HUMAN (378-687): 2.51e-89: 282: 16.83
+	Hs
		440029 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		CDK3_HUMAN (378-688): 1e-90: 286: 17.09
+	Hs
		699657 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		KS6A3_HUMAN (2-362): 2.76e-77: 264: 13.83
+	Hs
		699759 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		KS6A2_HUMAN (2-343): 2.02e-76: 261: 16.44
+	Hs
		136390 P85B_HUMAN (21-380): 2.06e-23: 104: 12.80		KS6A2_HUMAN (2-343): 2.02e-76: 261: 16.44
+	Hs
		440452 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		KS6A3_HUMAN (2-362): 2.76e-77: 264: 13.83
+	Hs
		440568 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		KS6A2_HUMAN (2-343): 2.02e-76: 261: 16.44
+	Hs
		440570 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		KS6A1_HUMAN (2-343): 1.95e-75: 259: 14.76
+	Hs
		557185 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		KS6A3_HUMAN (2-362): 2.76e-77: 264: 13.83
+	Hs
		463100 YES_HUMAN (6-137): 1.81e-19: 91.7: 20.15		KS6A2_HUMAN (2-343): 2.02e-76: 261: 16.44
+	Hs
		841011 FRK_HUMAN (3-171): 1.38e-17: 86: 15.39		KS6A1_HUMAN (2-343): 1.95e-75: 259: 14.76
+	Hs
		287700 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		KS6A5_HUMAN (3-345): 5.53e-62: 223: 14.44
+	Hs
		463088 YES_HUMAN (6-137): 1.81e-19: 91.7: 20.15		KCC2G_HUMAN (376-686): 1.05e-29: 126: 16.51