HitPredict

Interactor 1: KALRN (O60229)
Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain)
Gene: KALRN

Interactor 2: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3, SH2~fn3, PH~PK_Tyr_Ser-Thr, PH~SH3_1, PK_Tyr_Ser-Thr~Pkinase, RhoGEF~SH3_1
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0035556 - intracellular signal transduction GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2986 Hs			1 509
+	Hs
		224699 KALRN_HUMAN (1-2986): 0: 2339: 100.00		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		279830 TRIO_HUMAN (23-2982): 0: 1941: 59.82		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		279832 TRIO_HUMAN (23-2982): 0: 1941: 59.82		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		164551 SPTN2_HUMAN (97-2001): 6.12e-110: 396: 12.34		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		411715 SPTN1_HUMAN (60-1728): 1.93e-87: 323: 13.27		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		164555 SPTN2_HUMAN (97-2001): 6.12e-110: 396: 12.34		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		411676 SPTB2_HUMAN (50-1615): 2.89e-77: 289: 12.00		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		433753 SPTN1_HUMAN (60-1728): 1.93e-87: 323: 13.27		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		433700 SPTB2_HUMAN (50-1615): 2.89e-77: 289: 12.00		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		337470 SPTN1_HUMAN (60-1728): 1.93e-87: 323: 13.27		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Dm
		337655 Q7YZA0_DROME (1260-1596): 6.62e-84: 293: 30.17		ABL_DROME (43-502): 3.42e-171: 525: 42.34
+	Hs
		442840 PKHG4_HUMAN (1277-1587): 7.94e-43: 175: 34.07		HCK_HUMAN (1-509): 0: 602: 65.04
+	Hs
		337406 DAPK1_HUMAN (2673-2942): 2.97e-62: 238: 41.73		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Hs
		411682 DYST_HUMAN (180-1107): 2.38e-15: 85.8: 11.45		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		411889 MACF1_HUMAN (18-548): 1.25e-13: 80.1: 11.71		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		297808 K0754_HUMAN (18-548): 8.25e-16: 87: 11.71		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		523003 MYLK_HUMAN (2357-2681): 1.75e-14: 82.7: 15.95		SRC_HUMAN (20-507): 0: 586: 55.00
+	Hs
		433710 DYST_HUMAN (180-1107): 2.38e-15: 85.8: 11.45		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		337296 SPTA1_HUMAN (843-1251): 6.32e-31: 136: 12.47		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Hs
		360640 SPTA1_HUMAN (843-1251): 6.32e-31: 136: 12.47		BTK_HUMAN (7-505): 1.49e-167: 490: 33.27